Conceptualising compensation in neurodevelopmental disorders: Reflections from autism spectrum disorder.
Conceptualising compensation in neurodevelopmental disorders: Reflections from autism spectrum disorder.
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DOI：
10.1016/j.neubiorev.2017.06.005
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发表时间：
2017-09
影响因子：
8.2
通讯作者：
Happé F
中科院分区：
文献类型：
--
作者：
Livingston LA;Happé F
补偿可能支持神经发育障碍症状的改善。人们对补偿的概念知之甚少，也没有商定的定义。我们得出了一个工作定义，并审查了补偿的证据（例如，在ASD中）。我们提出了一个初步的跨诊断补偿框架。我们讨论了潜在的神经认知机制和研究/临床意义。在对神经发育障碍的研究中，人们对发育过程中症状严重程度变化的机制知之甚少。当病症的行为表现改善/症状减轻时，这可能是因为认知/神经功能中的核心潜在能力得到改善。另一种可能性是“补偿”;尽管在认知和/或神经生物学水平上存在持续缺陷，但行为表现似乎有所改善。然而，目前对补偿或其行为、认知和神经特征没有商定的技术定义。此外，它在神经发育障碍中的作用尚未直接研究。在这里，我们回顾目前的证据补偿神经发育障碍，自闭症谱系障碍为例，为了走向更好的概念化的结构。我们提出了一个transdiagnosis框架，补偿代表的过程负责观察到的行为和潜在的认知之间的不匹配的神经发育障碍，在任何一个发展点。此外，我们探讨了潜在的认知和神经机制驱动补偿，并讨论了更广泛的相关性的概念在研究和临床设置。
Compensation may underpin improvements in symptoms in neurodevelopmental disorders. The construct of compensation is poorly understood and has no agreed definition. We derive a working definition and review evidence for compensation (e.g., in ASD). We propose a preliminary transdiagnostic framework of compensation. We discuss potential neurocognitive mechanisms and research/clinical implications. Within research into neurodevelopmental disorders, little is known about the mechanisms underpinning changes in symptom severity across development. When the behavioural presentation of a condition improves/symptoms lessen, this may be because core underlying atypicalities in cognition/neural function have ameliorated. An alternative possibility is ‘compensation’; that the behavioural presentation appears improved, despite persisting deficits at cognitive and/or neurobiological levels. There is, however, currently no agreed technical definition of compensation or its behavioural, cognitive and neural characteristics. Furthermore, its workings in neurodevelopmental disorders have not been studied directly. Here, we review current evidence for compensation in neurodevelopmental disorders, using Autism Spectrum Disorder as an example, in order to move towards a better conceptualisation of the construct. We propose a transdiagnostic framework, where compensation represents the processes responsible for an observed mismatch between behaviour and underlying cognition in a neurodevelopmental disorder, at any point in development. Further, we explore potential cognitive and neural mechanisms driving compensation and discuss the broader relevance of the concept within research and clinical settings.
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影响因子：
2.2
作者：
Bacon, Alison M.;Handley, Simon J.
通讯作者：
Handley, Simon J.
DOI：
10.1177/1362361315607724
发表时间：
2016-10
期刊：
Autism : the international journal of research and practice
影响因子：
--
作者：
Blumberg SJ;Zablotsky B;Avila RM;Colpe LJ;Pringle BA;Kogan MD
通讯作者：
Kogan MD
影响因子：
4.7
作者：
Anderson, George M.
通讯作者：
Anderson, George M.
影响因子：
7.6
作者：
Brunsdon, Victoria E. A.;Colvert, Emma;Happe, Francesca
通讯作者：
Happe, Francesca
影响因子：
3.9
作者：
Bargiela, Sarah;Steward, Robyn;Mandy, William
通讯作者：
Mandy, William