Neural circuits underlying thirst and fluid homeostasis.

Neural circuits underlying thirst and fluid homeostasis.
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DOI:
10.1038/nrn.2017.71
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发表时间:
2017-08
期刊:
Nature reviews. Neuroscience
影响因子:
--
通讯作者:
Knight ZA
Knight ZA
中科院分区:
其他
文献类型:
--
作者:
Zimmerman CA;Leib DE;Knight ZA

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口渴促使动物寻找和消耗水。四十多年前,一组相互关联的大脑结构被称为终板(LT),它控制着口渴。然而,由于这些大脑区域的解剖学复杂性,其底层神经回路的结构和动力学仍然不清楚。最近,新的神经记录和操纵工具的出现重振了对这一回路的研究,并促使人们重新审视长期存在的关于口渴的神经起源的问题。在这里,我们回顾这些进展,讨论他们教我们控制饮酒行为,并概述了仍然没有答案的关键问题。
Thirst motivates animals to find and consume water. More than forty years ago, a set of interconnected brain structures known as the lamina terminalis (LT) was identified that governs thirst. However, due to the anatomical complexity of these brain regions, the structure and dynamics of their underlying neural circuitry has remained obscure. Recently, the emergence of new tools for neural recording and manipulation has reinvigorated the study of this circuit and prompted reexamination of longstanding questions about the neural origins of thirst. Here we review these advances, discuss what they teach us about the control of drinking behavior, and outline the key questions that remain unanswered.
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