Specialized ribosomes: a new frontier in gene regulation and organismal biology.
Specialized ribosomes: a new frontier in gene regulation and organismal biology.
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DOI：
10.1038/nrm3359
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发表时间：
2012-05-23
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影响因子：
--
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中科院分区：
文献类型：
--
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历史上，核糖体被认为是一种复杂的核酶，在mRNA翻译中具有组成性而不是内在的调节能力。然而，新兴的研究表明核糖体的活性可能受到高度调节。核糖体蛋白、核糖体RNA （rRNA）多样性和核糖体相关因子的活性的差异表达和翻译后修饰导致核糖体组成的异质性可能产生“特化核糖体”，这对基因组模板如何翻译成功能蛋白有重大影响。此外，核糖体的组成成分也可能通过与特定mRNA调控元件（如内部核糖体进入位点（IRESs）或上游开放阅读框（uorf））的相互作用而发挥更特殊的活性。在这里，我们讨论核糖体的内在调控作用是选择性地翻译含有独特顺式调控元件的mrna亚群，从而在基因表达和生物体的生命中引入额外的调控水平。
Historically, the ribosome has been viewed as a complex ribozyme with constitutive rather than intrinsic regulatory capacity in mRNA translation. However, emerging studies reveal that ribosome activity may be highly regulated. Heterogeneity in ribosome composition resulting from differential expression and post-translational modifications of ribosomal proteins, ribosomal RNA (rRNA) diversity and the activity of ribosome-associated factors may generate ‘specialized ribosomes’ that have a substantial impact on how the genomic template is translated into functional proteins. Moreover, constitutive components of the ribosome may also exert more specialized activities by virtue of their interactions with specific mRNA regulatory elements such as internal ribosome entry sites (IRESs) or upstream open reading frames (uORFs). Here we discuss the hypothesis that intrinsic regulation by the ribosome acts to selectively translate subsets of mRNAs harbouring unique cis-regulatory elements, thereby introducing an additional level of regulation in gene expression and the life of an organism.
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影响因子：
3.9
作者：
Boria, Ilenia;Garelli, Emanuela;Gazda, Hanna T.;Aspesi, Anna;Quarello, Paola;Pavesi, Elisa;Ferrante, Daniela;Meerpohl, Joerg J.;Kartal, Mutlu;Da Costa, Lydie;Proust, Alexis;Leblanc, Thierry;Simansour, Maud;Dahl, Niklas;Froejmark, Anne-Sophie;Pospisilova, Dagmar;Cmejla, Radek;Beggs, Alan H.;Sheen, Mee R.;Landowski, Michael;Buros, Christopher M.;Clinton, Catherine M.;Dobson, Lori J.;Vlachos, Adrianna;Atsidaftos, Eva;Lipton, Jeffrey M.;Ellis, Steven R.;Ramenghi, Ugo;Dianzani, Irma
通讯作者：
Dianzani, Irma
影响因子：
2.6
作者：
Amikura, R;Sato, K;Kobayashi, S
通讯作者：
Kobayashi, S
DOI：
10.1073/pnas.171286998
发表时间：
2001-07-31
影响因子：
11.1
作者：
Amikura, R;Kashikawa, M;Kobayashi, S
通讯作者：
Kobayashi, S
影响因子：
5.6
作者：
CRICK, FHC
通讯作者：
CRICK, FHC
影响因子：
5.8
作者：
Bortoluzzi, S;d'Alessi, F;Danieli, GA
通讯作者：
Danieli, GA