The elimination of fox rabies from Europe: determinants of success and lessons for the future.
The elimination of fox rabies from Europe: determinants of success and lessons for the future.
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DOI：
10.1098/rstb.2012.0142
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发表时间：
2013-08-05
期刊：
影响因子：
--
通讯作者：
Müller T
中科院分区：
文献类型：
--
作者：
Freuling CM;Hampson K;Selhorst T;Schröder R;Meslin FX;Mettenleiter TC;Müller T
尽管在控制野生动物传染病方面存在挑战，但狐狸口服狂犬病疫苗（ORV）已被证明是一种非常成功的工具，也是消除野生动物宿主疾病的复杂策略的主要例子。在过去的三十年中，在24个国家实施了ORV计划，导致西欧和中欧广大地区消除了狐狸介导的狂犬病。在这项研究中，我们评估了1978年至2010年间22个欧洲ORV计划的效率。在此期间，至少有一次针对近190万平方公里的地区使用了疫苗诱饵，根据国家的不同，控制时间在5至26年之间。我们研究了影响控制和消除狐狸狂犬病所需努力的因素以及这些方案的成本相关问题。曾受狂犬病影响的土地面积的比例和捕获连续ORV运动的规模和重叠的指数被确定为对控制和消除狂犬病所需的运动数量具有统计学显著影响的因素。重复进行完全重叠的全面运动，可以更快地消除感染，而且从长远来看成本更低。在ORV计划的最后阶段，需要付出不成比例的更大努力，一旦发病率降低90%，就需要额外开展11次运动，如果连续的ORV运动遍及整个受影响地区，狂犬病将比不太全面的运动更快地被消灭，因此从长远来看减少了ORV支出。这些发现将有助于改善ORV计划的规划和实施，并促进兽医当局和政策制定者未来的决策。
Despite perceived challenges to controlling an infectious disease in wildlife, oral rabies vaccination (ORV) of foxes has proved a remarkably successful tool and a prime example of a sophisticated strategy to eliminate disease from wildlife reservoirs. During the past three decades, the implementation of ORV programmes in 24 countries has led to the elimination of fox-mediated rabies from vast areas of Western and Central Europe. In this study, we evaluated the efficiency of 22 European ORV programmes between 1978 and 2010. During this period an area of almost 1.9 million km² was targeted at least once with vaccine baits, with control taking between 5 and 26 years depending upon the country. We examined factors influencing effort required both to control and eliminate fox rabies as well as cost-related issues of these programmes. The proportion of land area ever affected by rabies and an index capturing the size and overlap of successive ORV campaigns were identified as factors having statistically significant effects on the number of campaigns required to both control and eliminate rabies. Repeat comprehensive campaigns that are wholly overlapping much more rapidly eliminate infection and are less costly in the long term. Disproportionally greater effort is required in the final phase of an ORV programme, with a median of 11 additional campaigns required to eliminate disease once incidence has been reduced by 90 per cent. If successive ORV campaigns span the entire affected area, rabies will be eliminated more rapidly than if campaigns are implemented in a less comprehensive manner, therefore reducing ORV expenditure in the longer term. These findings should help improve the planning and implementation of ORV programmes, and facilitate future decision-making by veterinary authorities and policy-makers.
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DOI：
10.20506/rst.18.2.1174
发表时间：
1999-08-01
期刊：
REVUE SCIENTIFIQUE ET TECHNIQUE DE L OFFICE INTERNATIONAL DES EPIZOOTIES
影响因子：
--
作者：
Aubert, MFA
通讯作者：
Aubert, MFA
影响因子：
3.8
作者：
Cliquet, Florence;Robardet, Emmanuelle;Niin, Enel
通讯作者：
Niin, Enel
影响因子：
5.5
作者：
Dowdle, Walter R.;Cochi, Stephen L.
通讯作者：
Cochi, Stephen L.
影响因子：
3.3
作者：
BROCHIER, BM;LANGUET, B;PASTORET, PP
通讯作者：
PASTORET, PP
影响因子：
5
作者：
BAER, GM;ABELSETH, MK;DEBBIE, JG
通讯作者：
DEBBIE, JG