Characterisation of portal hypertension models by microspheres in anaesthetised rats: a comparison of liver flow.

Characterisation of portal hypertension models by microspheres in anaesthetised rats: a comparison of liver flow.
复制标题

麻醉大鼠微球门脉高压模型的表征:肝流量的比较。

DOI:
10.1016/s0163-7258(01)00123-1
复制
发表时间:
2001
影响因子:
13.5
通讯作者:
J. Reichen
J. Reichen
中科院分区:
医学1区
文献类型:
--
作者:
M. Van de Casteele;H. Sägesser;H. Zimmermann;J. Reichen

文献摘要

参考文献

被引文献

相似文献

有几种门静脉高压动物模型可用于血流动力学研究。门静脉流入,测量微球在戊巴比妥麻醉大鼠,在这里进行了比较。部分门静脉结扎模型的特征在于门静脉流入量高,同时伴有广泛的门体分流,代价是门静脉窦血流。在四氯化碳诱导的小结节性肝硬化中,到达肝实质的门静脉窦血流量较高,这在腹水存在时更为明显。在胆管结扎和切除诱导的肝硬化中,肝重量的增加并不等同于门静脉窦血流的增加,这表明肝脏灌注相对不足。
Several portal hypertensive animal models are available and frequently used for haemodynamic studies. The portal venous inflows, measured with microspheres in pentobarbital anaesthetised rats, are compared here. The partial portal vein ligation model is characterised by a high portal venous inflow, together with extensive portal systemic shunting, at the cost of portal sinusoidal flow. In carbon tetrachloride-induced micronodular cirrhosis, portal sinusoidal flow, which reaches liver parenchyma, is high, and this is more pronounced in the presence of ascites. In bile duct ligation and excision-induced cirrhosis, an increase in liver weight was not equally followed by an increase in portal sinusoidal flow, pointing to a relatively underperfused liver.
大鼠的血流动力学紊乱与注射的微球数量有关。
DOI: 10.1152/ajpheart.1983.245.6.h920
发表时间: 1983
期刊: The American journal of physiology
影响因子: --
作者:
Stanek,KA;Smith,TL;Murphy,WR;Coleman,TG
通讯作者: Coleman,TG
通过恢复正常的肝血流消除门静脉分流的代谢异常。
DOI: 10.1152/ajpendo.1996.270.6.e1037
发表时间: 1996
期刊: The American journal of physiology
影响因子: --
作者:
Hawkins,PA;DeJoseph,MR;Hawkins,RA
通讯作者: Hawkins,RA
慢性门脉高压:对胃肠道血流分布的影响。
DOI: 10.1152/ajpgi.1986.250.4.g535
发表时间: 1986
期刊: The American journal of physiology
影响因子: --
作者:
Benoit,JN;Womack,WA;Korthuis,RJ;Wilborn,WH;Granger,DN
通讯作者: Granger,DN