Clinical relevance of cellular mediators of inflammation in workers exposed to asbestos.
Clinical relevance of cellular mediators of inflammation in workers exposed to asbestos.
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接触石棉的工人炎症细胞介质的临床相关性。
DOI：
10.1164/ajrccm/148.1.68
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发表时间：
1993
期刊：
影响因子：
--
通讯作者：
Hunninghake,GW
中科院分区：
文献类型：
--
作者：
Schwartz,DA;Galvin,JR;Frees,KL;Dayton,CS;Burmeister,LF;Merchant,JA;Hunninghake,GW
为了确定接触石棉的工人中炎症细胞介质的临床相关性，我们研究了主要由肺泡巨噬细胞释放的炎症产物与石棉诱导的间质纤维化的临床表达之间的关系。我们的研究人群包括93名白色男性，他们在职业上暴露于石棉，平均年龄为60岁。对几乎所有研究受试者进行肺功能检查、胸部X线片、高分辨率CT扫描和支气管肺泡灌洗（BAL）; 11例（11.8%）肺功能受限，22例（23.7%）气体交换异常，30例（32.3%）胸部X线片显示间质纤维化，24例（25.8%）高分辨率CT扫描显示间质改变。我们检测的实质性炎症的细胞标志物包括在未刺激和内毒素（LPS）刺激的培养条件下BAL液中的纤维连接蛋白和肺泡巨噬细胞释放前列腺素E2（PGE 2）、白细胞介素-1 β（IL-1β）和肿瘤坏死因子（TNF-α）。在肺功能受限的患者中，观察到BAL液中纤维连接蛋白的浓度显著较高。此外，从培养但未受刺激的肺泡巨噬细胞释放的较高浓度的PGE 2与限制性肺功能相关。而在气体交换异常的受试者中，观察到与PGE 2的负相关。有趣的是，在那些在胸片或高分辨率CT扫描上发现间质性改变的患者中，没有观察到这些炎症介质的一致变化。此外，在未刺激或LPS刺激的培养条件下，肺泡巨噬细胞释放的IL-1β和TNF-α的浓度与石棉诱导的间质纤维化的生理或放射学表达无显著相关。总之，我们的研究结果表明，在接触石棉的工人中，主要来自肺泡巨噬细胞的细胞产物似乎与石棉诱导的间质性肺病的轻度放射学表现无关。然而，从培养的肺泡巨噬细胞释放的较高浓度的纤连蛋白和PGE 2似乎与限制性肺功能有关。
To identify the clinical relevance of cellular mediators of inflammation in workers exposed to asbestos, we investigated the relationship between inflammatory products primarily released by alveolar macrophages and the clinical expression of asbestos-induced interstitial fibrosis. Our study population consisted of 93 white men who had been occupationally exposed to asbestos and were on average 60 yr of age. Pulmonary function tests, chest radiographs, high-resolution CT scans, and bronchoalveolar lavage (BAL) were performed on almost all study subjects; 11 (11.8%) had restrictive lung function, 22 (23.7%) had abnormal gas exchange, 30 (32.3%) had interstitial fibrosis on chest x-ray, and 24 (25.8%) had interstitial changes on high-resolution CT scan. The cellular markers of parenchymal inflammation that we examined included fibronectin in BAL fluid and alveolar macrophage release of prostaglandin E2(PGE2), interleukin-1β (IL-1β), and tumor necrosis factor (TNF-α) under unstimulated and endotoxin (LPS)-stimulated culture conditions. Significantly higher concentrations of fibronectin in BAL fluid were observed among those with restrictive lung function. In addition, higher concentrations of PGE2, released from cultured but otherwise unstimulated alveolar macrophages, were associated with restrictive lung function. However, the inverse relationship with PGE2was observed among subjects with abnormal gas exchange. Interestingly, no consistent changes in these inflammatory mediators were observed in those with interstitial changes identified on either the chest radiograph or the high-resolution CT scan. Moreover, the concentration of IL-1β and TNF-α released by alveolar macrophages under either unstimulated or LPS-stimulated culture conditions were not significantly related to the physiologic or radiographic expression of asbestos-induced interstitial fibrosis. In aggregate, our results suggest that among workers exposed to asbestos, cell products primarily derived from alveolar macrophages do not appear to be associated with mild radiographic manifestations of asbestos-induced interstitial lung disease. However, higher concentrations of fibronectin and PGE2released from cultured alveolar macrophages appear to be associated with restrictive lung function.
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石棉引起的胸膜纤维化和肺功能受损。
DOI：
--
发表时间：
1990
期刊：
American Review of Respiratory Disease
影响因子：
--
作者：
D. A. Schwartz;L. Fuortes;J. Galvin;L. Burmeister;Lynn E. Schmidt;B. Leistikow;F. P. LaMarte;J. Merchant
通讯作者：
J. Merchant
石棉工人支气管肺泡灌洗液中的淋巴细胞亚群。
DOI：
--
发表时间：
1985
期刊：
American Review of Respiratory Disease
影响因子：
--
作者：
A. Gellert;M. Macey;S. Uthayakumar;A. Newland;R. Rudd
通讯作者：
R. Rudd
吸入石棉后肺泡巨噬细胞 Ia 抗原表达增强。
影响因子：
4.4
作者：
D. Hartmann;M. Georgian;E. Kagan
通讯作者：
E. Kagan
影响因子：
19.7
作者：
STAPLES, CA;MULLER, NL;MILLER, RR
通讯作者：
MILLER, RR
影响因子：
3.5
作者：
ROM, WN
通讯作者：
ROM, WN