Automated segmentation and fractal analysis of high-resolution non-invasive capillary perfusion maps of the human retina.
Automated segmentation and fractal analysis of high-resolution non-invasive capillary perfusion maps of the human retina.
复制标题
DOI：
10.1016/j.mvr.2013.06.008
复制
发表时间：
2013-09
影响因子：
3.1
通讯作者：
Wang J
中科院分区：
文献类型：
--
作者：
Jiang H;Debuc DC;Rundek T;Lam BL;Wright CB;Shen M;Tao A;Wang J
视网膜为研究脑血管疾病的病理生理学提供了一个窗口。病理性视网膜微血管变化可能反映大脑中的微血管病变过程。光学成像技术的最新进展使得能够在毛细血管水平上对视网膜微脉管系统进行成像，并利用视网膜功能成像仪 (RFI) 生成高分辨率、非侵入性毛细血管灌注图 (nCPM)。然而，缺乏对 nCPM 的定量分析可能会限制该方法在临床研究中的更广泛应用。该项目的目标是证明 nCPM 自动分割和分形分析的可行性。我们对 6 名健康志愿者组成的小组中的每个受试者进行了两次 nCPM，并使用我们的分割算法对单分形和多重分形分析进行自动分割。单分形维数为1.885±0.020，多重分形维数为1.876±0.010（P=0.108）。单分形分析的重复性系数为 0.070，多重分形分析的重复性系数为 0.026。这项研究表明，nCPM 的自动分割对于分形分析是可行的。单分形和多重分形分析都得出相似的结果。毛细血管水平的微血管定量分析可能为脑小血管疾病等微血管疾病的研究开辟新纪元。
The retina provides a window to study the pathophysiology of cerebrovascular diseases. Pathological retinal microvascular changes may reflect microangiopathic processes in the brain. Recent advances in optical imaging techniques have enabled imaging of the retinal microvasculature at the capillary level, and the generation of high-resolution, non-invasive capillary perfusion maps (nCPMs) with the Retinal Function Imager (RFI). However, the lack of quantitative analyses of the nCPMs may limit the wider application of the method in clinical research. The goal of this project was to demonstrate the feasibility of automated segmentation and fractal analysis of nCPMs. We took two nCPMs of each subject in a group of 6 healthy volunteers and used our segmentation algorithm to do the automated segmentation for monofractal and multifractal analyses. The monofractal dimension was 1.885 ± 0.020, and the multifractal dimension was 1.876 ± 0.010 (P =0.108). The coefficient of repeatability was 0.070 for monofractal analysis and 0.026 for multifractal analysis. This study demonstrated that the automatic segmentation of nCPMs is feasible for fractal analyses. Both monofractal and multifractal analyses yielded similar results. The quantitative analyses of microvasculature at the capillary level may open up a new era for studying the microvascular diseases such as cerebral small vessel disease.
登录
查看更多内容
影响因子：
16.2
作者：
Cheung, Ning;Donaghue, Kim C.;Liew, Gerald;Rogers, Sophie L.;Wang, Jie Jin;Lim, Shueh-Wen;Jenkins, Alicia J.;Hsu, Wynne;Lee, Mong Li;Wong, Tien Y.
通讯作者：
Wong, Tien Y.
影响因子：
120.7
作者：
Wong, TY;Klein, R;Mosley, TH
通讯作者：
Mosley, TH
影响因子：
11.2
作者：
Cheung, Ning;Liew, Gerald;Wong, Tien Y.
通讯作者：
Wong, Tien Y.
影响因子：
9.9
作者：
Doubal, F. N.;MacGillivray, T. J.;Wardlaw, J. M.
通讯作者：
Wardlaw, J. M.
影响因子：
4.2
作者：
Witkin, Andre J.;Alshareef, Rayan A.;Garg, Sunir J.
通讯作者：
Garg, Sunir J.