The ArcAB two-component regulatory system promotes resistance to reactive oxygen species and systemic infection by Salmonella Typhimurium.
The ArcAB two-component regulatory system promotes resistance to reactive oxygen species and systemic infection by Salmonella Typhimurium.
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DOI：
10.1371/journal.pone.0203497
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发表时间：
2018
期刊：
影响因子：
3.7
通讯作者：
Saavedra CP
中科院分区：
文献类型：
--
作者：
Pardo-Esté C;Hidalgo AA;Aguirre C;Briones AC;Cabezas CE;Castro-Severyn J;Fuentes JA;Opazo CM;Riedel CA;Otero C;Pacheco R;Valvano MA;Saavedra CP
沙门氏菌（Salmonella enterica Serovar Typhimurium）鼠伤寒沙门氏菌）是一种细胞内细菌，其克服宿主免疫系统屏障以成功感染。细菌定植于近端小肠，穿透上皮层，并被巨噬细胞和中性粒细胞吞噬。胞内S.鼠伤寒遇到高毒性的活性氧，包括过氧化氢和次氯酸。沙门氏菌抵抗细胞内氧化应激的分子机制还不完全清楚。ArcAB双组分系统是一个对氧气做出响应的全球调节系统。在这项工作中，我们表明，ArcA反应调节剂参与沙门氏菌适应不断变化的氧气水平，也参与促进巨噬细胞和中性粒细胞的细胞内存活，使沙门氏菌。鼠伤寒沙门氏菌成功建立全身感染。
Salmonella enterica Serovar Typhimurium (S. Typhimurium) is an intracellular bacterium that overcomes host immune system barriers for successful infection. The bacterium colonizes the proximal small intestine, penetrates the epithelial layer, and is engulfed by macrophages and neutrophils. Intracellularly, S. Typhimurium encounters highly toxic reactive oxygen species including hydrogen peroxide and hypochlorous acid. The molecular mechanisms of Salmonella resistance to intracellular oxidative stress is not completely understood. The ArcAB two-component system is a global regulatory system that responds to oxygen. In this work, we show that the ArcA response regulator participates in Salmonella adaptation to changing oxygen levels and is also involved in promoting intracellular survival in macrophages and neutrophils, enabling S. Typhimurium to successfully establish a systemic infection.
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影响因子：
16.6
作者：
Chakraborty S;Winardhi RS;Morgan LK;Yan J;Kenney LJ
通讯作者：
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影响因子：
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作者：
ISHIGE, K;NAGASAWA, S;MIZUNO, T
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MIZUNO, T
DOI：
10.1073/pnas.85.6.1888
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11.1
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