Tuberculosis and COVID-19 interaction: A review of biological, clinical and public health effects.
Tuberculosis and COVID-19 interaction: A review of biological, clinical and public health effects.
复制标题
结核病和COVID-19相互作用：生物学，临床和公共卫生影响的综述。
DOI：
10.1016/j.pulmoe.2020.12.012
复制
发表时间：
2021-03
期刊：
影响因子：
11.7
通讯作者：
Goletti D
中科院分区：
文献类型：
--
作者：
Visca D;Ong CWM;Tiberi S;Centis R;D'Ambrosio L;Chen B;Mueller J;Mueller P;Duarte R;Dalcolmo M;Sotgiu G;Migliori GB;Goletti D
关于结核病（TB）和COVID-19之间相互作用的证据正在积累。本综述的目的是报告这两种感染之间相互作用的现有证据。讨论了结核病和COVID-19的差异和相似之处，它们的免疫学特征，诊断，流行病学和临床特征以及公共卫生影响。审查了关于这一专题的主要出版文件和准则。基于所涉及的免疫学机制，已发现COVID-19和TB中免疫反应的共同失调，这表明合并感染造成的双重风险使COVID-19严重程度恶化并有利于TB疾病进展。临床方面的现有证据表明，无论在活动性结核病诊断之前、期间或之后是否发生结核病，COVID-19都会发生。需要更多的证据来确定COVID-19是否可能重新激活或恶化活动性结核病。同样，在治疗COVID-19的初始阶段处方的药物的潜在作用及其与抗结核药物的相互作用需要谨慎。关于发病率和死亡率的风险，已经确定了COVID-19的几个风险评分和结核病的独立风险因素：其中包括年龄、贫困、营养不良和合并症（艾滋病毒合并感染、糖尿病等）。预计正在进行的全球结核病/新冠肺炎研究将提供更多证据。
Evidence is accumulating on the interaction between tuberculosis (TB) and COVID-19. The aim of the present review is to report the available evidence on the interaction between these two infections. Differences and similarities of TB and COVID-19, their immunological features, diagnostics, epidemiological and clinical characteristics and public health implications are discussed. The key published documents and guidelines on the topic have been reviewed. Based on the immunological mechanism involved, a shared dysregulation of immune responses in COVID-19 and TB has been found, suggesting a dual risk posed by co-infection worsening COVID-19 severity and favouring TB disease progression. The available evidence on clinical aspects suggests that COVID-19 happens regardless of TB occurrence either before, during or after an active TB diagnosis. More evidence is required to determine if COVID-19 may reactivate or worsen active TB disease. The role of sequeale and the need for further rehabilitation must be further studied Similarly, the potential role of drugs prescribed during the initial phase to treat COVID-19 and their interaction with anti-TB drugs require caution. Regarding risk of morbidity and mortality, several risk scores for COVID-19 and independent risk factors for TB have been identified: including, among others, age, poverty, malnutrition and co-morbidities (HIV co-infection, diabetes, etc.). Additional evidence is expected to be provided by the ongoing global TB/COVID-19 study.
登录
查看更多内容
影响因子：
8.7
作者：
Cliff JM;Kaufmann SH;McShane H;van Helden P;O'Garra A
通讯作者：
O'Garra A
影响因子：
15.1
作者：
Cilloni L;Fu H;Vesga JF;Dowdy D;Pretorius C;Ahmedov S;Nair SA;Mosneaga A;Masini E;Sahu S;Arinaminpathy N
通讯作者：
Arinaminpathy N
影响因子：
7.3
作者：
Afkhami S;Villela AD;D'Agostino MR;Jeyanathan M;Gillgrass A;Xing Z
通讯作者：
Xing Z
影响因子：
3.9
作者：
Czumbel, Laszlo Mark;Kiss, Szabolcs;Varga, Gabor
通讯作者：
Varga, Gabor
影响因子：
6.4
作者：
Falasca, Laura;Nardacci, Roberta;Del Nonno, Franca
通讯作者：
Del Nonno, Franca