3D Printing in Solid Dosage Forms and Organ-on-Chip Applications.
3D Printing in Solid Dosage Forms and Organ-on-Chip Applications.
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DOI：
10.3390/bios12040186
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发表时间：
2022-03-22
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影响因子：
--
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3D打印（3DP）不仅可以作为生产定制个性化给药方案的固体剂型的优秀平台，而且还可以用作创建药物筛选，传感，测试和器官芯片应用的合适3D模型的工具。在过去的十年中，已经开发了几种新技术，将传统的给药方案转化为个性化药物。随着3DP技术生产的第一种药物制剂Spritam的批准，该技术引起了全球制药研究人员的关注。一直在努力改进工艺并减轻其他缺点，如赋形剂选择受限、时间限制、工业生产限制和总成本。本综述的目的是概述3DP工艺，其类型，所用材料的类型，以及每种技术在应用中的优缺点，不仅可以创建固体剂型，还可以生成用于感测，测试和筛选物质的3D模型。除了药物本身的产生之外，产生用于药物的生物传感和筛选的模型的应用为3DP在药剂学中的应用提供了一个完整的循环。
3D printing (3DP) can serve not only as an excellent platform for producing solid dosage forms tailored to individualized dosing regimens but can also be used as a tool for creating a suitable 3D model for drug screening, sensing, testing and organ-on-chip applications. Several new technologies have been developed to convert the conventional dosing regimen into personalized medicine for the past decade. With the approval of Spritam, the first pharmaceutical formulation produced by 3DP technology, this technology has caught the attention of pharmaceutical researchers worldwide. Consistent efforts are being made to improvise the process and mitigate other shortcomings such as restricted excipient choice, time constraints, industrial production constraints, and overall cost. The objective of this review is to provide an overview of the 3DP process, its types, types of material used, and the pros and cons of each technique in the application of not only creating solid dosage forms but also producing a 3D model for sensing, testing, and screening of the substances. The application of producing a model for the biosensing and screening of drugs besides the creation of the drug itself, offers a complete loop of application for 3DP in pharmaceutics.
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