Malaria parasite density and detailed qualitative microscopy enhances large-scale profiling of infection endemicity in Nigeria
Malaria parasite density and detailed qualitative microscopy enhances large-scale profiling of infection endemicity in Nigeria
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疟疾寄生虫密度和详细的定性显微镜增强了尼日利亚感染流行情况的大规模分析
DOI：
10.1101/2022.10.18.22281220
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Oyibo W
中科院分区：
文献类型：
--
作者：
Oyibo W
由于全球在减少疟疾方面的进展停滞不前，需要进一步分析流行病学，特别是在负担最重的国家。国家调查大多分析了感染流行情况，而很少有关于寄生虫密度和不同发育形式的大规模数据。尼日利亚是全球负担最重的国家，在2018年全国人口与健康调查中对5岁以下儿童进行了血液玻片显微镜检查，此前报告了寄生虫流行情况。在目前的研究中，报告并分析了该国六个地缘政治区域内36个州的7783名儿童的疟疾寄生虫密度测量结果。分析了无性和有性阶段，以及不同疟疾寄生虫种类的感染。在尼日利亚所有州，感染个体内的平均无性寄生虫密度与社区感染流行率呈正相关（Spearman’s rho = 0.39, P = 0.02）。无性寄生虫密度在北部地缘政治区最高（几何平均值bb0 2000 μL−1），进一步证明了许多地区异常高的感染负担。各区性虫密度均较低（几何平均值均< 100 μL−1），但性虫感染率与无性虫感染率高度相关（Spearman’s rho = 0.70, P < 0.001）。婴儿的寄生虫密度低于1岁以上儿童，但男女儿童之间没有差异。大多数感染是p。恶性疟原虫的无性寄生密度高于恶性疟原虫，而有性寄生密度低于恶性疟原虫。malariaeorP。ovalemono-infections。而混合种感染的无性寄生密度最高。建议今后在高负担国家进行大规模调查，测量寄生虫密度以及发育阶段和物种，以提高疟疾流行病学和跟踪未来变化的质量。
With global progress towards malaria reduction stalling, further analysis of epidemiology is required, particularly in countries with the highest burden. National surveys have mostly analysed infection prevalence, while large-scale data on parasite density and different developmental forms rarely available. In Nigeria, the country with the largest burden globally, blood slide microscopy of children up to 5 years of age was conducted in the 2018 National Demographic and Health Survey, and parasite prevalence previously reported. In the current study, malaria parasite density measurements are reported and analysed for 7783 of the children sampled across the 36 states within the six geopolitical zones of the country. Asexual and sexual stages, and infections with different malaria parasite species are analysed. Across all states of Nigeria, there was a positive correlation between mean asexual parasite density within infected individuals and prevalence of infection in the community (Spearman’s rho = 0.39, P = 0.02). Asexual parasite densities were highest in the northern geopolitical zones (geometric means > 2000 μL−1), extending the evidence of exceptionally high infection burden in many areas. Sexual parasite prevalence in each state was highly correlated with asexual parasite prevalence (Spearman’s rho = 0.70, P < 0.001), although sexual parasite densities were low (geometric means < 100 μL−1in all zones). Infants had lower parasite densities than children above 1 year of age, but there were no differences between male and female children. Most infections were ofP. falciparum, which had higher asexual densities but lower sexual parasite densities thanP. malariaeorP. ovalemono-infections. However, mixed species infections had the highest asexual parasite densities. It is recommended that future large surveys in high burden countries measure parasite densities as well as developmental stages and species, to improve the quality of malaria epidemiology and tracking of future changes.
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影响因子：
3
作者：
D'Alessandro U;Ubben D;Hamed K;Ceesay SJ;Okebe J;Taal M;Lama EK;Keita M;Koivogui L;Nahum A;Bojang K;Sonko AA;Lalya HF;Brabin B
通讯作者：
Brabin B
影响因子：
2.4
作者：
RICHIE, TL
通讯作者：
RICHIE, TL
影响因子：
16.6
作者：
Slater, Hannah C.;Ross, Amanda;Okell, Lucy C.
通讯作者：
Okell, Lucy C.
DOI：
10.4269/ajtmh.2008.78.442
发表时间：
2008-03-01
影响因子：
3.3
作者：
Bousema, J. Teun;Drakeley, Chris J.;Sauerwein, Robert W.
通讯作者：
Sauerwein, Robert W.
尼日利亚西南部无症状疟原虫携带者中，三日疟原虫和卵形疟原虫与恶性疟原虫合并感染的比例很高
DOI：
--
发表时间：
2021
期刊：
medRxiv
影响因子：
--
作者：
Muhydeen Abiodun Abdulraheem;M. Ernest;I. Ugwuanyi;H. M. Abkallo;Saori Nishikawa;M. Adeleke;Adebola E. Orimadegun;R. Culleton
通讯作者：
R. Culleton