Circulating levels of carbamylated protein and neutrophil extracellular traps are associated with periodontitis severity in patients with rheumatoid arthritis: A pilot case-control study.
Circulating levels of carbamylated protein and neutrophil extracellular traps are associated with periodontitis severity in patients with rheumatoid arthritis: A pilot case-control study.
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DOI：
10.1371/journal.pone.0192365
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发表时间：
2018
期刊：
影响因子：
3.7
通讯作者：
Yoshie H
中科院分区：
文献类型：
--
作者：
Kaneko C;Kobayashi T;Ito S;Sugita N;Murasawa A;Nakazono K;Yoshie H
类风湿性关节炎(RA)和牙周炎之间的相互关系已被认为是由于它们共同的致病机制。蛋白质氨甲酰化和中性粒细胞胞外陷阱(NETs)的形成与包括类风湿性关节炎在内的自身免疫疾病有关，但它们与牙周炎的关系尚未阐明。因此，我们评估了循环中的氨基甲酰化蛋白(CARP)和NETS水平是否与牙周炎的严重程度相关，并受到牙周治疗的影响。我们进行了一项回顾性病例对照研究，包括40例RA合并牙周炎患者、30例牙周炎患者和43例系统和牙周健康对照，以评估鲤鱼和Net的循环水平以及风湿病和牙周状况。22例类风湿性关节炎和牙周炎患者在牙周治疗2个月后也进行了同样的评估，包括口腔卫生指导和全口牙龈上刮治。类风湿性关节炎和牙周炎患者血清中CAP和NETS水平均显著高于正常对照组(P<0.001)。在40例RA和牙周炎患者中，血清CAP和NETS水平与牙周探诊深度(P=0.01P=0.007)和临床附着水平(P=0.007和P=0.001)的平均值呈显著正相关。多因素Logistic回归分析还显示，血清鲤鱼和NETs水平与中重度牙周炎呈显著正相关(P=0.03和P=0.001)。此外，牙周治疗还能显著降低RA和牙周炎患者的血清CAP和NETS水平(P=0.03和P=0.02)。在RA患者中，循环中的CAP和NETs水平与牙周炎严重程度相关，并受牙周治疗的影响。
An interrelationship between rheumatoid arthritis (RA) and periodontitis has been suggested due to their common pathogenic mechanisms. Protein carbamylation and neutrophil extracellular traps (NETs) formation have been shown to be related to autoimmune conditions, including RA, but their association with periodontitis has not been elucidated. Therefore, we assessed whether or not circulating levels of carbamylated protein (CarP) and NETs are associated with periodontitis severity and influenced by periodontal treatment. We conducted a retrospective case-control study that included 40 patients with RA and periodontitis, 30 patients with periodontitis, and 43 systemically and periodontally healthy controls to assess the circulating levels of CarP and NETs and rheumatologic and periodontal conditions. The same assessments were also performed in 22 patients with RA and periodontitis after 2 months of periodontal treatment, including oral hygiene instruction and full-mouth supragingival scaling. Patients with RA and periodontitis showed significantly higher serum levels of CarP and NETs than the control group (P = 0.04 and P < 0.001, respectively). The serum levels of CarP and NETs were significantly correlated positively with the mean values of probing depth (P = 0.01 and P = 0.007, respectively) and clinical attachment level (P = 0.007 and P = 0.001, respectively) in the 40 patients with RA and periodontitis. Multiple logistic regression analyses also revealed significantly positive associations between the serum levels of CarP and NETs and moderate to severe periodontitis (P = 0.03 and P = 0.001, respectively). Furthermore, periodontal treatment significantly decreased the serum levels of CarP and NETs in patients with RA and periodontitis (P = 0.03 and P = 0.02). The circulating levels of CarP and NETs are associated with periodontitis severity and influenced by periodontal treatment in patients with RA.
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