Transient Receptor Potential Channels and Botulinum Neurotoxins in Chronic Pain.
Transient Receptor Potential Channels and Botulinum Neurotoxins in Chronic Pain.
复制标题
DOI：
10.3389/fnmol.2021.772719
复制
发表时间：
2021
影响因子：
4.8
通讯作者：
Park CK
中科院分区：
文献类型：
--
作者：
Go EJ;Ji J;Kim YH;Berta T;Park CK
全球有超过 15 亿人遭受疼痛困扰，其中数亿人患有无法缓解的慢性疼痛。尽管人们普遍认识到开发更好的干预措施来缓解慢性疼痛的重要性，但人们对这种情况的潜在机制知之甚少。然而，伤害感受器中的瞬时受体电位（TRP）离子通道已被证明在疼痛的产生和进展中发挥重要作用，并作为治疗靶点引起了多家制药公司的关注。不幸的是，TRP 通道抑制剂在临床试验中失败了，至少部分是由于它们的体温调节功能。肉毒杆菌神经毒素（BoNT）因其对胞吐作用和促伤害性神经递质的调节而成为新型且安全的疼痛治疗剂。然而，越来越明显的是，BoNT 还调节 TRP 通道的表达和功能，这可能解释了它们的镇痛作用。在这里，我们总结了 TRP 通道在疼痛中的作用，特别关注 TRPV1 和 TRPA1 及其受 BoNT 的调节，并简要讨论了 BoNT 在治疗慢性疼痛中的应用。
Pain afflicts more than 1.5 billion people worldwide, with hundreds of millions suffering from unrelieved chronic pain. Despite widespread recognition of the importance of developing better interventions for the relief of chronic pain, little is known about the mechanisms underlying this condition. However, transient receptor potential (TRP) ion channels in nociceptors have been shown to be essential players in the generation and progression of pain and have attracted the attention of several pharmaceutical companies as therapeutic targets. Unfortunately, TRP channel inhibitors have failed in clinical trials, at least in part due to their thermoregulatory function. Botulinum neurotoxins (BoNTs) have emerged as novel and safe pain therapeutics because of their regulation of exocytosis and pro-nociceptive neurotransmitters. However, it is becoming evident that BoNTs also regulate the expression and function of TRP channels, which may explain their analgesic effects. Here, we summarize the roles of TRP channels in pain, with a particular focus on TRPV1 and TRPA1, their regulation by BoNTs, and briefly discuss the use of BoNTs for the treatment of chronic pain.
登录
查看更多内容
影响因子：
4.2
作者：
Fonfria E;Maignel J;Lezmi S;Martin V;Splevins A;Shubber S;Kalinichev M;Foster K;Picaut P;Krupp J
通讯作者：
Krupp J
影响因子：
8.6
作者：
GREENE, PE;FAHN, S
通讯作者：
FAHN, S
影响因子：
64.8
作者：
Chuang, HH;Prescott, ED;Julius, D
通讯作者：
Julius, D
影响因子：
13.9
作者：
Costigan M;Scholz J;Woolf CJ
通讯作者：
Woolf CJ
影响因子：
7.4
作者：
Gazerani, Parisa;Staahl, Camilla;Arendt-Nielson, Lars
通讯作者：
Arendt-Nielson, Lars