Transient and Persistent Representations of Odor Value in Prefrontal Cortex.
Transient and Persistent Representations of Odor Value in Prefrontal Cortex.
复制标题
气味值在前额叶皮层的瞬时和持续表征。
DOI：
10.1016/j.neuron.2020.07.033
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发表时间：
2020-10-14
期刊：
影响因子：
16.2
通讯作者：
Axel R
中科院分区：
文献类型：
--
作者：
Wang PY;Boboila C;Chin M;Higashi-Howard A;Shamash P;Wu Z;Stein NP;Abbott LF;Axel R
嗅觉皮质(梨状)中气味的表征是分布的和非结构化的，只有在学习后才能被赋予行为意义。随着小鼠学会嗅觉联系，我们进行了双光子成像，以检查梨状和两个下游区域--眼眶前额叶皮质(OFC)和内侧前额叶皮质(MPFC)--气味的表现。在梨状肌中，我们观察到气味反应在学习过程中基本没有变化。在OFC中，30%的神经元在学习后对条件刺激(CS+)获得了强烈的反应，这些反应受到内部状态和任务背景的制约。此外，梨状肌到OFC的直接投射可以诱导习得的嗅觉行为。随着训练的继续，OFC的CS+反应减弱，而在mPFC出现了CS+和CS−气味的持续表征。光遗传沉默表明，这两个大脑结构依次发挥作用，巩固对食欲联系的学习。Wang等人。在有食欲的学习过程中，检查梨状皮质和两个下游区域OFC和mPFC的气味表征。他们观察到梨形气味标识的表征以及OFC和mPFC的价值表征。此外，OFC和mPFC在学习食欲联想的过程中依次发挥作用。
The representation of odor in olfactory cortex (piriform) is distributive and unstructured and can only be afforded behavioral significance upon learning. We performed 2-photon imaging to examine the representation of odors in piriform and in two downstream areas, the orbitofrontal cortex (OFC) and the medial prefrontal cortex (mPFC), as mice learned olfactory associations. In piriform, we observed that odor responses were largely unchanged during learning. In OFC, 30% of the neurons acquired robust responses to conditioned stimuli (CS+) after learning, and these responses were gated by internal state and task context. Moreover, direct projections from piriform to OFC can be entrained to elicit learned olfactory behavior. CS+ responses in OFC diminished with continued training, whereas persistent representations of both CS+ and CS− odors emerged in mPFC. Optogenetic silencing indicates that these two brain structures function sequentially to consolidate the learning of appetitive associations. Wang et al. examine representations of odors in piriform cortex and two downstream areas, OFC and mPFC, during appetitive learning. They observe a representation of odor identity in piriform and representations of value in OFC and mPFC. Moreover, OFC and mPFC function sequentially in the learning of appetitive associations.
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影响因子：
64.8
作者：
Ghosh, Sulagna;Larson, Stephen D.;Baldwin, Kristin K.
通讯作者：
Baldwin, Kristin K.
影响因子：
2.5
作者：
Boulland, JL;Qureshi, T;Chaudhry, FA
通讯作者：
Chaudhry, FA
影响因子：
64.8
作者：
Burke, Kathryn A.;Franz, Theresa M.;Schoenbaum, Geoffrey
通讯作者：
Schoenbaum, Geoffrey
DOI：
10.1523/jneurosci.2820-08.2008
发表时间：
2008-10-29
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Bissonette GB;Martins GJ;Franz TM;Harper ES;Schoenbaum G;Powell EM
通讯作者：
Powell EM
影响因子：
48
作者：
Barretto, Robert P. J.;Messerschmidt, Bernhard;Schnitzer, Mark J.
通讯作者：
Schnitzer, Mark J.