Ventral Hippocampus Modulates Anxiety-Like Behavior in Male But Not Female C57BL/6 J Mice
Ventral Hippocampus Modulates Anxiety-Like Behavior in Male But Not Female C57BL/6 J Mice
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腹侧海马调节雄性而非雌性 C57BL/6 J 小鼠的焦虑样行为
DOI：
10.1016/j.neuroscience.2019.08.032
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发表时间：
2019-10
期刊：
影响因子：
3.3
通讯作者：
Yi Ming
中科院分区：
文献类型：
--
作者：
Wang Cheng;Zhang Yu;Shao Shan;Cui Shuang;Wan You;Yi Ming
在包括焦虑在内的情绪处理方面观察到显着的性别差异。海马体，特别是它的腹侧极，调节啮齿类动物的焦虑样行为。然而，大多数研究仅在雄性动物中进行，而海马体对雌性焦虑的调节作用尚不清楚。在本研究中，我们发现，在雄性而非雌性 C57BL/6J 小鼠的三项行为测试（新奇抑制进食、弹珠埋藏和高架十字迷宫）中，用鹅膏菌酸对腹侧海马进行兴奋性毒性损伤会产生抗焦虑作用。两种性别的损伤后，在开放区域的运动仍然相似。在高架十字迷宫中探索后，在雄性小鼠的腹侧海马中观察到比雌性小鼠更多的 c-Fos 阳性神经元，表明该区域在雄性小鼠的焦虑样行为中具有更强的参与性。这些结果揭示了小鼠腹侧海马对焦虑的调节存在显着的生物性别差异，为焦虑调节和海马功能提供了新的视角。
Remarkable sex difference has been observed in emotional processing including anxiety. The hippocampus, its ventral pole in particular, modulates anxiety-like behavior in rodents. However, most researches have been performed in male animals only, leaving hippocampal modulation of anxiety in females poorly defined. In the present study, we showed that excitotoxic lesioning of the ventral hippocampus with ibotenic acid produced anxiolytic effects in three behavioral tests (novelty-suppressed feeding, marble burying, and elevated-plus maze) in male but not female C57BL/6 J mice. Locomotion in the open field remained similar after lesioning in either sex. More c-Fos-positive neurons were observed in the ventral hippocampus in male than in female mice after exploration in an elevated plus-maze, indicating stronger enrollment of this region in anxiety-like behavior in males. These results reveal significant biological sex difference in ventral hippocampal modulation on anxiety in mice and provide a new sight for anxiety modulation and hippocampal function.
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影响因子：
10.6
作者：
Bath, Kevin G.;Chuang, Jocelyn;Spencer-Segal, Joanna L.;Amso, Dima;Altemus, Margaret;McEwen, Bruce S.;Lee, Francis S.
通讯作者：
Lee, Francis S.
DOI：
10.1111/j.1601-183x.2009.00476.x
发表时间：
2009-06
期刊：
Genes, brain, and behavior
影响因子：
--
作者：
Gangitano D;Salas R;Teng Y;Perez E;De Biasi M
通讯作者：
De Biasi M
影响因子：
16.2
作者：
Padilla-Coreano N;Bolkan SS;Pierce GM;Blackman DR;Hardin WD;Garcia-Garcia AL;Spellman TJ;Gordon JA
通讯作者：
Gordon JA
影响因子：
16.2
作者：
Fanselow, Michael S.;Dong, Hong-Wei
通讯作者：
Dong, Hong-Wei
影响因子：
10.6
作者：
Davidson, RJ
通讯作者：
Davidson, RJ