Diabetes in patients with idiopathic Parkinson's disease.
Diabetes in patients with idiopathic Parkinson's disease.
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DOI：
10.2337/dc08-0479
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发表时间：
2008-09
期刊：
影响因子：
16.2
通讯作者：
Meier CR
中科院分区：
文献类型：
--
作者：
Becker C;Brobert GP;Johansson S;Jick SS;Meier CR
目的：先前的观察性研究报告了糖尿病和帕金森病之间不一致的关联结果，并且关于帕金森病发生偶发糖尿病风险的数据很少。我们的目的是比较患有或不患有帕金森病的患者之间的糖尿病患病率，并探讨发生与帕金森病相关的偶发糖尿病的风险。研究设计和方法：我们使用英国的全科医学研究数据库（GPRD）， 1)比较1994年至2005年间帕金森病患者与未患帕金森病患者的匹配对照组的糖尿病患病率；2)进行一项随访研究，采用套式病例对照分析，量化帕金森病患者新发糖尿病的风险。结果：帕金森病患者和非帕金森病患者的糖尿病患病率相似（校正优势比[OR] 0.95 [95% CI 0.80-1.14]）。在队列分析（发病率比[IRR] 0.55 [95% CI 0.38-0.81]）和巢式病例对照分析（校正OR 0.53 [95% CI 0.33-0.87]）中，帕金森病患者患糖尿病的风险低于无帕金森病患者。目前使用5种或更多左旋多巴处方的帕金森病患者的调整OR为0.22(0.10-0.48)，未使用左旋多巴的帕金森病患者的调整OR为1.11（0.50-2.45）。结论：在这项观察性研究中，帕金森病患者和非帕金森病患者的糖尿病患病率非常相似。帕金森氏症患者发生偶发糖尿病的风险低于非帕金森氏症患者，这一发现仅限于使用左旋多巴的帕金森氏症患者。
OBJECTIVE—Previous observational studies reported inconsistent results on the association between diabetes and Parkinson's disease, and data on the risk of developing incident diabetes in relation to Parkinson's disease are scarce. We aimed at comparing the diabetes prevalence between patients with or without Parkinson's disease and at exploring the risk of developing incident diabetes associated with Parkinson's disease. RESEARCH DESIGN AND METHODS—We used the U.K.-based General Practice Research Database (GPRD) to 1) compare the diabetes prevalence between Parkinson's disease cases and a matched comparison group free of Parkinson's disease between 1994 and 2005 and to 2) conduct a follow-up study with a nested case-control analysis to quantify the risk of developing new-onset diabetes in association with Parkinson's disease. RESULTS—The diabetes prevalence was similar in patients with and without Parkinson's disease (adjusted odds ratio [OR] 0.95 [95% CI 0.80–1.14]). In the cohort analysis (incidence rate ratio [IRR] 0.55 [95% CI 0.38–0.81]) and in the nested case-control analysis (adjusted OR 0.53 [95% CI 0.33–0.87]), the risk of developing diabetes was lower in patients with Parkinson's disease than in subjects without. The adjusted OR for patients with Parkinson's disease who were current levodopa users of five or more prescriptions was 0.22 (0.10–0.48) and was 1.11 (0.50–2.45) for Parkinson's disease patients not using levodopa. CONCLUSIONS—In this observational study, diabetes prevalence was closely similar between patients with Parkinson's disease and subjects without. The risk of developing incident diabetes was lower for patients with Parkinson's disease than for patients without, a finding that was limited to Parkinson's disease patients who were using levodopa.
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影响因子：
16.2
作者：
Hu, Gang;Jousilahti, Pekka;Tuomilehto, Jaakko
通讯作者：
Tuomilehto, Jaakko
影响因子：
4.2
作者：
Wood, L;Martinez, C
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Martinez, C
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11.2
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Hernán, MA;Takkouche, B;Gestal-Otero, JJ
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Gestal-Otero, JJ
影响因子：
9.9
作者：
Simon, Kelly Claire;Chen, Honglei;Ascherio, Alberto
通讯作者：
Ascherio, Alberto
影响因子：
9.9
作者：
Hu, G.;Jousilahti, P.;Tuomilehto, J.
通讯作者：
Tuomilehto, J.