(±)3,4-methylenedioxymethamphetamine ("ecstasy") treatment modulates expression of neurotrophins and their receptors in multiple regions of adult rat brain.
(±)3,4-methylenedioxymethamphetamine ("ecstasy") treatment modulates expression of neurotrophins and their receptors in multiple regions of adult rat brain.
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DOI：
10.1002/cne.23048
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发表时间：
2012-08-01
影响因子：
2.5
通讯作者：
Seroogy, Kim B.
中科院分区：
文献类型：
--
作者：
Hemmerle, Ann M.;Dickerson, Jonathan W.;Herring, Nicole R.;Schaefer, Tori L.;Vorhees, Charles V.;Williams, Michael T.;Seroogy, Kim B.
（±）3，4-亚甲二氧基甲基苯丙胺（MDMA）是一种广泛使用的滥用药物，当摄入或给予足量时，可迅速降低大脑中的5-羟色胺水平，导致基于复杂路线的学习、空间学习和参考记忆缺陷。神经营养因子对于成人脑中神经元（包括多巴胺能神经元）的存活和保存是重要的。在这项研究中，我们研究了MDMA对脑源性神经营养因子（BDNF）和神经营养因子-3（NT-3）及其各自的高亲和力受体，原肌球蛋白受体激酶（trk）B和trkC在大鼠大脑多个区域表达的影响。向成年Sprague-Dawley大鼠给予MDMA（10 mg/kg × 4，每天间隔2小时），末次给药后1、7或24小时检查大脑。通过使用cRNA探针原位杂交分析BDNF、NT-3、trkB和trkC的信使RNA水平。前额叶皮层特别容易受到MDMA诱导的BDNF，NT-3，trkB和trkC mRNA在多个时间点都上调的变化。MDMA处理的动物在额叶、顶叶、梨状和内嗅皮质中的BDNF表达增加，在前扣带皮质中的NT-3表达增加，并且内嗅皮质中的trkC升高。在黑质纹状体系统中，BDNF的表达上调，在黑质parsapranta，和trkB在纹状体中的MDA治疗的动物升高。神经营养因子和trkB在海马结构的几个区域差异调节。这些发现表明神经营养蛋白信号传导可能在MDMA治疗后出现的学习和记忆缺陷中发挥作用。
(±)3,4-Methylenedioxymethamphetamine (MDMA), a widely used drug of abuse, rapidly reduces serotonin levels in the brain when ingested or administered in sufficient quantities, resulting in deficits in complex route-based learning, spatial learning, and reference memory. Neurotrophins are important for survival and preservation of neurons in the adult brain, including serotonergic neurons. In this study, we examined the effects of MDMA on the expression of brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3) and their respective high-affinity receptors, tropomyosin receptor kinase (trk)B and trkC, in multiple regions of the rat brain. A serotonergic-depleting dose of MDMA (10 mg/kg × 4 at 2-hour intervals on a single day) was administered to adult Sprague-Dawley rats, and brains were examined 1, 7, or 24 hours after the last dose. Messenger RNA levels of BDNF, NT-3, trkB, and trkC were analyzed by using in situ hybridization with cRNA probes. The prefrontal cortex was particularly vulnerable to MDMA-induced alterations in that BDNF, NT-3, trkB, and trkC mRNAs were all upregulated at multiple time points. MDMA-treated animals had increased BDNF expression in the frontal, parietal, piriform, and entorhinal cortices, increased NT-3 expression in the anterior cingulate cortex, and elevated trkC in the entorhinal cortex. In the nigrostriatal system, BDNF expression was upregulated in the substantia nigra pars compacta, and trkB was elevated in the striatum in MDMA-treated animals. Both neurotrophins and trkB were differentially regulated in several regions of the hippocampal formation. These findings suggest a possible role for neurotrophin signaling in the learning and memory deficits seen following MDMA treatment.
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DOI：
10.1002/neu.480240907
发表时间：
1993-09-01
期刊：
JOURNAL OF NEUROBIOLOGY
影响因子：
--
作者：
JELSMA, TN;FRIEDMAN, HH;AGUAYO, AJ
通讯作者：
AGUAYO, AJ
影响因子：
5.3
作者：
Hicks, RR;Martin, VB;Seroogy, KB
通讯作者：
Seroogy, KB
影响因子：
2.9
作者：
Hatami, Homeira;Oryan, Shahrbanoo;Ahmadiani, Abolhassan
通讯作者：
Ahmadiani, Abolhassan
DOI：
10.1016/s0169-328x(97)00158-7
发表时间：
1997-09-01
期刊：
MOLECULAR BRAIN RESEARCH
影响因子：
--
作者：
Hicks, RR;Numan, S;Seroogy, KB
通讯作者：
Seroogy, KB
影响因子：
3.3
作者：
Baumann, M. H.;Clark, R. D.;Rothman, R. B.
通讯作者：
Rothman, R. B.