Nontraditional risk factors for cardiovascular disease and visceral adiposity index among different body size phenotypes.
Nontraditional risk factors for cardiovascular disease and visceral adiposity index among different body size phenotypes.
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DOI：
10.1016/j.numecd.2014.07.006
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发表时间：
2015-01
期刊：
影响因子：
--
通讯作者：
Yu X
中科院分区：
文献类型：
--
作者：
Du T;Zhang J;Yuan G;Zhang M;Zhou X;Liu Z;Sun X;Yu X
新陈代谢健康肥胖(MHO)患者心血管疾病和死亡风险的增加仍然存在很大争议。几项研究表明存在风险，而其他研究则没有。传统的心血管危险因素可能不足以显示MHO个体的全部代谢异常。因此，我们旨在比较6种体型(正常体重伴或不伴代谢异常、超重伴或不伴代谢异常、超重伴或不伴代谢异常、肥胖伴或不伴代谢异常)中脂蛋白(A)、载脂蛋白B和尿酸(UA)水平、载脂蛋白B/载脂蛋白A1比值、内脏脂肪指数(VAI)和低载脂蛋白A1水平升高的发生率。我们利用2009年全国中国健康与营养调查数据，对7,765名中国成年人进行了横断面分析。在代谢健康的正常体重(MHNW)和代谢异常的肥胖者之间，MHO患者的载脂蛋白B和UA水平、载脂蛋白B/载脂蛋白A1比率和血管活性指数评分中等偏高，而载脂蛋白A1水平偏低(P<；所有比较均为0.001)。升高的载脂蛋白B和尿酸浓度、载脂蛋白B/载脂蛋白A1比值和VAI评分均与MHO表型密切相关(均P<；0.01)。MHO患者中载脂蛋白B和UA水平升高、载脂蛋白B/载脂蛋白A1比值和VAI评分升高以及载脂蛋白A1水平降低的发生率高于MHNW患者。MHO患者非传统危险因素水平和VAI评分的升高可能是长期研究中观察到的心血管疾病风险增加的原因之一。
Increased cardiovascular disease and mortality risk in metabolically healthy obese (MHO) individuals remain highly controversial. Several studies suggested risk while others do not. The traditional cardiovascular risk factors may be insufficient to demonstrate the complete range of metabolic abnormalities in MHO individuals. Hence, we aimed to compare the prevalence of elevated lipoprotein (a), apolipoprotein B, and uric acid (UA) levels, apolipoprotein B/apolipoprotein A1 ratio, and visceral adiposity index (VAI) scores, and low apolipoprotein A1 levels among 6 body size phenotypes (normal weight with and without metabolic abnormalities, overweight with and without metabolic abnormalities, and obese with or without metabolic abnormalities). We conducted a cross-sectional analysis of 7765 Chinese adults using data from the nationwide China Health and Nutrition Survey 2009. MHO persons had intermediate prevalence of elevated apolipoprotein B and UA levels, apolipoprotein B/apolipoprotein A1 ratio and VAI scores, and low apolipoprotein A1 levels between metabolically healthy normal-weight (MHNW) and metabolically abnormal obese individuals (P < 0.001 for all comparisons). Elevated apolipoprotein B and UA concentrations, apolipoprotein B/apolipoprotein A1 ratio, and VAI scores were all strongly associated with the MHO phenotype (all P < 0.01). Prevalence of elevated apolipoprotein B and UA levels, apolipoprotein B/apolipoprotein A1 ratio and VAI scores, and low levels of apolipoprotein A1 was higher among MHO persons than among MHNW individuals. The elevated levels of the nontraditional risk factors and VAI scores in MHO persons could contribute to the increased cardiovascular disease risk observed in long-term studies.
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