Facile production of nanocomposites of carbon nanotubes and polycaprolactone with high aspect ratios with potential applications in drug delivery.
Facile production of nanocomposites of carbon nanotubes and polycaprolactone with high aspect ratios with potential applications in drug delivery.
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DOI：
10.1039/c7ra13553j
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发表时间：
2018-05-07
期刊：
影响因子：
3.9
通讯作者：
McDonald TO
中科院分区：
文献类型：
--
作者：
Niezabitowska E;Smith J;Prestly MR;Akhtar R;von Aulock FW;Lavallée Y;Ali-Boucetta H;McDonald TO
纳米载体的几何结构和表面性质在很大程度上影响着纳米材料与活细胞的相互作用。在这项工作中，我们将多壁碳纳米管(CNT)与聚ε-己内酯(PCL)相结合，通过简单的乳液溶剂挥发法制备了高长径比的非球形纳米复合材料。用动态光散射(DLS)、扫描电子显微镜(SEM)、原子力显微镜(AFM)和非对称流场流动分馏(AF4)对颗粒进行了表征。根据十二烷基硫酸钠(十二烷基硫酸钠)、碳纳米管和聚己内酯的浓度不同，可以得到不同尺寸和形貌的纳米颗粒。用1.5mgmL十二烷基硫酸钠、0.9mgmLCNTs和10mgmLPCL分别得到了低分散度的棒状−-−-CNT纳米结构。AFM分析表明，PCL和PCL-CNT纳米复合材料的弹性模数分别为770和560 Mpa，说明所有的碳纳米管表面都覆盖了至少2 nm的PCL。热重分析表明PCL-CNT纳米复合材料中碳纳米管的质量分数为9.6%。样品的非对称流场分馏表明，PCL-CNT的流体力学直径比单独的PCL大。最后，以多西紫杉醇为活性物质对纳米复合材料的载药性能进行了评价。纳米复合材料显示多西紫杉醇(%)的包封率与碳纳米管(95%)和聚己内酯纳米粒(81%)相当。这是一种简便的获得非球形纳米复合材料的方法，它结合了PCL和碳纳米管的高长径比、高弹性系数等性质。这些纳米复合材料具有很高的药物包封率，在药物输送方面有很好的应用前景。制备聚合物碳纳米管纳米复合材料的简便方法。
The geometries and surface properties of nanocarriers greatly influence the interaction between nanomaterials and living cells. In this work we combine multiwalled carbon nanotubes (CNTs) with poly-ε-caprolactone (PCL) to produce non-spherical nanocomposites with high aspect ratios by using a facile emulsion solvent evaporation method. Particles were characterised by dynamic light scattering (DLS), scanning electron microscopy (SEM), atomic force microscopy (AFM) and asymmetric flow field flow fractionation (AF4). Different sizes and morphologies of nanoparticles were produced depending on the concentration of the sodium dodecyl sulphate (SDS), CNTs and PCL. Rod-like PCL-CNT nanostructures with low polydispersity were obtained with 1.5 mg mL−1 of SDS, 0.9 mg mL−1 of CNTs and 10 mg mL−1 PCL. AFM analysis revealed that the PCL and PCL-CNT nanocomposite had comparatively similar moduli of 770 and 560 MPa respectively, indicating that all the CNTs have been coated with at least 2 nm of PCL. Thermogravimetric analysis of the PCL-CNT nanocomposite indicated that they contained 9.6% CNTs by mass. The asymmetric flow field flow fractionation of the samples revealed that the PCL-CNT had larger hydrodynamic diameters than PCL alone. Finally, the drug loading properties of the nanocomposites were assessed using docetaxel as the active substance. The nanocomposites showed comparable entrapment efficiencies of docetaxel (89%) to the CNTs alone (95%) and the PCL nanoparticles alone (81%). This is a facile method for obtaining non-spherical nanocomposites that combines the properties of PCL and CNTs such as the high aspect ratio, modulus. The high drug entrapment efficiency of these nanocomposites may have promising applications in drug delivery. Facile route to polymer carbon nanotube nanocomposites.
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影响因子：
10.8
作者：
Champion, Julie A.;Katare, Yogesh K.;Mitragotri, Samir
通讯作者：
Mitragotri, Samir
DOI：
10.1164/rccm.200504-613pp
发表时间：
2005-12-15
影响因子：
24.7
作者：
Gelperina, S;Kisich, K;Heifets, L
通讯作者：
Heifets, L
影响因子：
4.3
作者：
Gigault, Julien;Cho, Tae Joon;Hackley, Vincent A.
通讯作者：
Hackley, Vincent A.
影响因子：
3.2
作者：
Horie, Masanori;Stowe, Mayumi;Fujita, Katsuhide
通讯作者：
Fujita, Katsuhide
DOI：
10.1016/j.jconrel.2016.07.051
发表时间：
2016-09-28
期刊：
Journal of controlled release : official journal of the Controlled Release Society
影响因子：
--
作者：
Banerjee A;Qi J;Gogoi R;Wong J;Mitragotri S
通讯作者：
Mitragotri S