An outbreak of tuberculosis due to Mycobacterium bovis infection in a pack of English Foxhounds (2016-2017).
An outbreak of tuberculosis due to Mycobacterium bovis infection in a pack of English Foxhounds (2016-2017).
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DOI：
10.1111/tbed.12969
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发表时间：
2018-12
影响因子：
4.3
通讯作者：
Gunn-Moore DA
中科院分区：
文献类型：
--
作者：
O'Halloran C;Hope JC;Dobromylskyj M;Burr P;McDonald K;Rhodes S;Roberts T;Dampney R;De la Rua-Domenech R;Robinson N;Gunn-Moore DA
牛分枝杆菌可在包括狮子、牛和人在内的群居哺乳动物中引起结核病，但犬类感染被认为是罕见的。在2016/17年度，我们调查了英格兰牛结核病边缘地区约180只猎狐犬的牛分枝杆菌结核病暴发。我们采用了免疫试验的组合，包括干扰素γ释放试验（IGRA）和血清学试验（DPP VetTB, Chembio）。测试阳性的狗被安乐死并进行尸检（PME）。总共测试了164只猎犬；97%（59%）至少对一项测试有积极反应。85只（52%）犬通过IGRA对牛支原体抗原有应答，而仅有21只（12.9%）犬有可检测到的血清学应答。在PME时，3只狗（3.1%）由于牛分枝杆菌感染而出现可见病变（VL），后来通过培养证实。从24只非VL犬中提取样本进行培养，另外3只犬（11%）被证实感染了牛支原体。本研究是首次对犬类中牛分枝杆菌结核暴发的调查和报告。我们确定，原则上，用于识别其他物种感染个体的诊断测试可以有效地用于狗。为了将来的临床应用，迫切需要进一步的工作来建立本研究中使用的检测方法的敏感性和特异性。
Mycobacterium bovis can cause tuberculosis (TB) in social mammals including lions, cattle and man, but canine infections are considered rare. In 2016/17 we investigated a M. bovis TB outbreak in a pack of approximately 180 Foxhounds within the bovine TB Edge Area of England. We employed a combination of immunological tests including an interferon gamma release assay (IGRA) and a serological assay (DPP VetTB, Chembio). Test‐positive hounds were euthanased and subjected to post‐mortem examination (PME). Overall 164 hounds were tested; 97 (59%) responded positively to at least one test. Eighty‐five (52%) dogs responded to M. bovis antigens by IGRA while only 21 (12.9%) had detectable serological responses. At PME three hounds (3.1%) had visible lesions (VL) due to M. bovis infection, later confirmed by culture. Samples from 24 non‐VL hounds were cultured and M. bovis infection was confirmed in a further three hounds (11%). This study is the first investigation and report of an outbreak of M. bovis TB in a canine species. We establish that, in principle, diagnostic tests used for identifying infected individuals of other species can effectively be used in the dog. Further work is urgently needed to establish the sensitivity and specificity of the testing approach used in this study for future clinical application.
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影响因子：
2.2
作者：
Corner, Leigh A. L.;O'Meara, D.;Gormley, E.
通讯作者：
Gormley, E.
DOI：
10.1099/00221287-144-5-1189
发表时间：
1998-05-01
期刊：
MICROBIOLOGY-UK
影响因子：
--
作者：
Frothingham, R;Meeker-O'Connell, WA
通讯作者：
Meeker-O'Connell, WA
影响因子：
6.4
作者：
Junqueira-Kipnis, Ana Paula;Basaraba, Randall J.;Orme, Ian M.
通讯作者：
Orme, Ian M.
影响因子：
2.4
作者：
Bezos, Javier;Casal, Carmen;Dominguez, Lucas
通讯作者：
Dominguez, Lucas
影响因子：
2.2
作者：
Ellis, M. D.;Davies, S.;de la Rua-Domenech, R.
通讯作者：
de la Rua-Domenech, R.