Psychological well-being and the human conserved transcriptional response to adversity.
Psychological well-being and the human conserved transcriptional response to adversity.
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DOI：
10.1371/journal.pone.0121839
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Cole SW
中科院分区：
文献类型：
--
作者：
Fredrickson BL;Grewen KM;Algoe SB;Firestine AM;Arevalo JM;Ma J;Cole SW
人类社会基因组学研究已经确定了一种保守的逆境转录反应(CTRA)，其特征是促炎基因的表达上调，I型干扰素和抗体相关基因的表达下调。这份报告试图找出积极心理健康的特定方面，这些方面反对这种影响，并预测CTRA基因表达减少。在一项对122名健康成年人进行的新的验证性研究中，复制了之前报道的一项发现研究的方法，混合效应线性模型分析发现，CTRA指示基因的表达与心理健康连续体-缩写形式的幸福感汇总测量之间存在显著的负关联。对幸福感的2个表征的分析集中在发现幸福感的相关心理和社会亚域是CTRA协会的主要载体。享乐主义幸福感没有表现出独立于幸福感的一致的CTRA关联，综合享乐主义幸福感和幸福感的汇总指标显示，与幸福感(心理和社会幸福感)的焦点测量相比，CTRA关联性不稳定。对汇集的发现样本和确认样本(n=198)的分析也得出了类似的结果。对107名健康成年人进行的第二项新的泛化研究也得出了类似的结果，该研究包括更详细的Ryff心理幸福感量表，并发现这种更稳健的幸福衡量标准也与CTRA基因表达减少有关。在心理幸福感的6个主要预测子域中，有5个在单独分析时降低了CTRA基因的表达，在相互调整的分析中，有3个仍然具有明显的预测作用。所有的相关性都与人口统计特征、健康相关的混杂因素和白细胞亚群分布的RNA指标无关。这些结果确定了幸福感的特定子维度作为未来干预措施的有希望的目标，以减轻CTRA基因的表达，并且不支持享乐主义幸福感的任何独立的有利贡献。
Research in human social genomics has identified a conserved transcriptional response to adversity (CTRA) characterized by up-regulated expression of pro-inflammatory genes and down-regulated expression of Type I interferon- and antibody-related genes. This report seeks to identify the specific aspects of positive psychological well-being that oppose such effects and predict reduced CTRA gene expression. In a new confirmation study of 122 healthy adults that replicated the approach of a previously reported discovery study, mixed effect linear model analyses identified a significant inverse association between expression of CTRA indicator genes and a summary measure of eudaimonic well-being from the Mental Health Continuum – Short Form. Analyses of a 2- representation of eudaimonia converged in finding correlated psychological and social subdomains of eudaimonic well-being to be the primary carriers of CTRA associations. Hedonic well-being showed no consistent CTRA association independent of eudaimonic well-being, and summary measures integrating hedonic and eudaimonic well-being showed less stable CTRA associations than did focal measures of eudaimonia (psychological and social well-being). Similar results emerged from analyses of pooled discovery and confirmation samples (n = 198). Similar results also emerged from analyses of a second new generalization study of 107 healthy adults that included the more detailed Ryff Scales of Psychological Well-being and found this more robust measure of eudaimonic well-being to also associate with reduced CTRA gene expression. Five of the 6 major sub-domains of psychological well-being predicted reduced CTRA gene expression when analyzed separately, and 3 remained distinctively prognostic in mutually adjusted analyses. All associations were independent of demographic characteristics, health-related confounders, and RNA indicators of leukocyte subset distribution. These results identify specific sub-dimensions of eudaimonic well-being as promising targets for future interventions to mitigate CTRA gene expression, and provide no support for any independent favorable contribution from hedonic well-being.
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影响因子：
12.7
作者：
Keyes, Corey L. M.;Myers, John M.;Kendler, Kenneth S.
通讯作者：
Kendler, Kenneth S.
DOI：
10.1073/pnas.1218253109
发表时间：
2012-12-11
影响因子：
11.1
作者：
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通讯作者：
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影响因子：
3.1
作者：
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通讯作者：
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影响因子：
5
作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
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