On the Dual Role of Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 (CEACAM1) in Human Malignancies.
On the Dual Role of Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 (CEACAM1) in Human Malignancies.
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DOI：
10.1155/2018/7169081
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发表时间：
2018
影响因子：
4.1
通讯作者：
Badarau IA
中科院分区：
文献类型：
--
作者：
Calinescu A;Turcu G;Nedelcu RI;Brinzea A;Hodorogea A;Antohe M;Diaconu C;Bleotu C;Pirici D;Jilaveanu LB;Ion DA;Badarau IA
癌胚抗原相关细胞粘附分子1 （CEACAM1）是一种属于癌胚抗原（CEA）家族的糖蛋白，在多种细胞上表达，并通过其交替剪接和各种异构体的产生在炎症中发挥复杂作用，介导复杂的调节和失调机制。CEACAM1最初被认为是一种肿瘤抑制因子，因为在许多实体癌的早期阶段，CEACAM1在上皮内的表达明显下调。最近，随着各种论文指出其在肿瘤进展、血管生成和侵袭中的作用，CEACAM1与恶性肿瘤的进展和转移性扩散有关。我们回顾了文献，讨论了CEACAM1在不同类型肿瘤中的不同表达模式，描述了其结构和一般生物学功能，并强调了将该分子与不良预后联系起来的最重要发现。了解CEACAM1在细胞转化中的作用的重要性不仅在于这种粘附分子作为预后因素的价值，还在于它作为一种潜在的新分子靶点可以作为一种特定的癌症治疗方法。
Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) is a glycoprotein belonging to the carcinoembryonic antigen (CEA) family that is expressed on a wide variety of cells and holds a complex role in inflammation through its alternate splicing and generation of various isoforms, mediating intricate mechanisms of modulation and dysregulation. Initially regarded as a tumor suppressor as its expression shows considerable downregulation within the epithelia in the early phases of many solid cancers, CEACAM1 has been linked lately to the progression of malignancy and metastatic spread as various papers point to its role in tumor progression, angiogenesis, and invasion. We reviewed the literature and discussed the various expression patterns of CEACAM1 in different types of tumors, describing its structure and general biologic functions and emphasizing the most significant findings that link this molecule to poor prognosis. The importance of understanding the role of CEACAM1 in cell transformation stands not only in this adhesion molecule's value as a prognostic factor but also in its promising premise as a potential new molecular target that could be exploited as a specific cancer therapy.
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影响因子：
8
作者：
Gerstel, D.;Wegwitz, F.;Horst, A. K.
通讯作者：
Horst, A. K.
影响因子：
16
作者：
Ergün, S;Kilic, N;Wagener, C
通讯作者：
Wagener, C
CEACAM1通过在肿瘤细胞上下调NKG2D配体的表达来抑制抗肿瘤免疫。
DOI：
10.1084/jem.20102575
发表时间：
2011-12-19
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Chen Z;Chen L;Baker K;Olszak T;Zeissig S;Huang YH;Kuo TT;Mandelboim O;Beauchemin N;Lanier LL;Blumberg RS
通讯作者：
Blumberg RS
DOI：
10.1084/jem.122.3.467
发表时间：
1965-09-01
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Gold P;Freedman SO
通讯作者：
Freedman SO
影响因子：
37.3
作者：
Gaur S;Shively JE;Yen Y;Gaur RK
通讯作者：
Gaur RK