Deceased donors as nondirected donors in kidney paired donation.
Deceased donors as nondirected donors in kidney paired donation.
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DOI：
10.1111/ajt.16268
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发表时间：
2021-01
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影响因子：
--
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作为概念证明，我们模拟了一个修订后的肾脏分配系统，该系统将已故供体（DD）肾脏作为肾配对捐赠池（KPDP）中的链启动肾脏（DD- cik），并估计移植数量的潜在增加。我们考虑长度为2的链，其中DD- cik捐赠给KPDP中的候选人，该候选人的不相容供体捐赠给已故供体（DD）等待名单。在模拟中，我们改变初始池大小、候选/供体对和（活的）非定向供体（ndd）的到达率，以及从进入KPDP到候选人有资格接收DD-CIK的延迟时间。使用来自配对肾脏捐赠联盟的候选/供体配对和ndd数据，以及来自移植受者科学登记（SRTR）数据的实际dd，模拟时间超过两年。初始库为400个，候选和NDD分别为每天2个和每月3个，获得DD-CIK的延迟时间为6个月或更短，包括DD-CIKs在内，两年内移植数量至少增加447例，并大大减少了KPDP候选人的等待时间。对候补候选人的潜在影响以及政策和道德问题进行了讨论。
As proof of concept, we simulate a revised kidney allocation system that includes deceased donor (DD) kidneys as chain-initiating kidneys (DD-CIK) in a kidney paired donation pool (KPDP), and estimate potential increases in number of transplants. We consider chains of length 2 in which the DD-CIK gives to a candidate in the KPDP, and that candidate’s incompatible donor donates to the deceased donor (DD) waitlist. In simulations, we vary initial pool size, arrival rates of candidate/donor pairs and (living) non-directed donors (NDDs), and delay time from entry to the KPDP until a candidate is eligible to receive a DD-CIK. Using data on candidate/donor pairs and NDDs from the Alliance for Paired Kidney Donation, and the actual DDs from the Scientific Registry of Transplant Recipients (SRTR) data, simulations extend over two years. With an initial pool of 400, respective candidate and NDD arrival rates of two per day and 3 per month, and delay times for access to DD-CIK of 6 months or less, including DD-CIKs increases the number of transplants by at least 447 over two years, and greatly reduces waiting times of KPDP candidates. Potential effects on waitlist candidates are discussed as are policy and ethical issues.
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影响因子：
1
作者：
Li, Yijiang;Song, Peter X. -K.;Kalbfleisch, John D.
通讯作者：
Kalbfleisch, John D.
影响因子：
168.9
作者：
Montgomery, Robert A.;Gentry, Sommer E.;Segev, Dorry L.
通讯作者：
Segev, Dorry L.
DOI：
10.1111/ajt.14744
发表时间：
2018-11
期刊：
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
影响因子：
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作者：
Flechner SM;Thomas AG;Ronin M;Veale JL;Leeser DB;Kapur S;Peipert JD;Segev DL;Henderson ML;Shaffer AA;Cooper M;Hil G;Waterman AD
通讯作者：
Waterman AD
影响因子：
13.7
作者：
Roth, AE;Sönmez, T;Ünver, MU
通讯作者：
Ünver, MU
影响因子：
6.2
作者：
Park, K;Moon, JI;Kim, YS
通讯作者：
Kim, YS