Invited commentary: low cholesterol and nonartherosclerotic disease risk: a persistently perplexing question.
Invited commentary: low cholesterol and nonartherosclerotic disease risk: a persistently perplexing question.
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特邀评论：低胆固醇和非动脉粥样硬化疾病风险：一个持续令人困惑的问题。
DOI：
10.1093/oxfordjournals.aje.a010273
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发表时间：
2000
影响因子：
5
通讯作者：
Iribarren,C
中科院分区：
文献类型：
--
作者：
JacobsJr,DR;Iribarren,C
与使用他汀类药物的临床试验相反，这些临床试验表明胆固醇从高水平降低到中等水平是安全的，许多但不是全部，前瞻性研究报告了血清总胆固醇低的人的非动脉粥样硬化疾病发生率较高，即使在排除胆固醇测定后5年内的死亡后。一个令人困惑和未回答的问题是低胆固醇是否与非动脉粥样硬化性疾病的风险有因果关系。胆固醇在急性期反应期间降低;持续5年以上的免疫激活状态可以解释前瞻性观察结果。较高的胆固醇可能是其他保护物质的标志，如脂溶性抗氧化剂。低胆固醇可能标志着营养不良，例如，在抑郁症期间。或者，较高的胆固醇水平可能导致在免疫应答或组织修复期间脂质向细胞的递送增强，或者可能增强对内毒素和病毒的防御。虽然我们认为，全民努力降低胆固醇应该继续下去，我们认为，重要的生物学可能反映在反复观察低胆固醇与非动脉粥样硬化性疾病的关联。作者敦促研究继续阐明这些关系的任何生物学基础。Am J Epidemiol 2000;151：748-51。
In contrast of clinical trials using statin drugs, which suggest that cholesterol lowering from high to moderate levels is safe, many but not all, prospective studies report higher nonatherosclerotic disease rates in people with low serum total cholesterol, even after deleting deaths in the 5 years after cholesterol determination. A perplexing and unanswered question is whether low cholesterol is causally related to nonatherosclerotic disease risk. Cholesterol is reduced during the acute phase reaction; a state of immune activation that persists for more than 5 years may explain the prospective observations. Higher cholesterol may be a marker for other protective substances such as fat-soluble antioxidants. Low cholesterol might mark poor nutrition, for example, during depression. Alternatively, higher cholesterol levels may result in enhanced delivery of lipids to cells during the immune response or tissue repair or may enhance defense against endotoxins and viruses. Although we believe that populationwide efforts to lower cholesterol should continue, we think that important biology may be reflected in the repeatedly observed associations of low cholesterol with nonatherosclerotic disease. The authors urge that research continue to elucidate any biologic bases of these relations.Am J Epidemiol2000;151:748–51.
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DOI：
10.1097/00042560-199801010-00008
发表时间：
1998-01-01
期刊：
JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES AND HUMAN RETROVIROLOGY
影响因子：
--
作者：
Claxton, AJ;Jacobs, DR;Feingold, KR
通讯作者：
Feingold, KR
抑郁症患者膳食摄入量是否充足。
影响因子：
3.5
作者：
L. Christensen;S. Somers
通讯作者：
S. Somers
老年人的脂蛋白改变和动脉粥样硬化。
影响因子：
4.4
作者：
M. Corti;G. Barbato;G. Baggio
通讯作者：
G. Baggio
饮食引起的血清胆固醇浓度变化不会改变沙鼠大脑中的色氨酸羟化率或血清素浓度。
影响因子：
6.1
作者：
Fernstrom,MH;Verrico,CD;Ebaugh,AL;Fernstrom,JD
通讯作者：
Fernstrom,JD
影响因子：
158.5
作者：
KLAG, MJ;FORD, DE;LEVINE, DM
通讯作者：
LEVINE, DM