Surface modification of neural electrodes with pyrrole-hyaluronic acid conjugate to attenuate reactive astrogliosis in vivo.
Surface modification of neural electrodes with pyrrole-hyaluronic acid conjugate to attenuate reactive astrogliosis in vivo.
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DOI:
10.1039/c5ra03294f
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发表时间:
2015
期刊:
影响因子:
3.9
通讯作者:
Schmidt, C. E.
中科院分区:
文献类型:
--
作者:
Lee, J. Y.;Khaing, Z. Z.;Siegel, J. J.;Schmidt, C. E.
Surface of neural probes were electrochemically modified with a non-cell adhesive and biocompatible conjugate, pyrrole-hyaluronic acid (PyHA), to reduce reactive astrogliosis. Poly(PyHA)-modified wire electrodes were implanted into rat motor cortices for three weeks and were found to markedly reduce the expression of glial fibrillary acidic protein compared to uncoated electrodes.
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