Surface modification of neural electrodes with pyrrole-hyaluronic acid conjugate to attenuate reactive astrogliosis in vivo.

Surface modification of neural electrodes with pyrrole-hyaluronic acid conjugate to attenuate reactive astrogliosis in vivo.
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DOI:
10.1039/c5ra03294f
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发表时间:
2015
期刊:
影响因子:
3.9
通讯作者:
Schmidt, C. E.
Schmidt, C. E.
中科院分区:
化学3区
文献类型:
--
作者:
Lee, J. Y.;Khaing, Z. Z.;Siegel, J. J.;Schmidt, C. E.

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用非细胞粘附性和生物相容性缀合物吡咯-透明质酸(PyHA)电化学修饰神经探针的表面,以减少反应性星形胶质细胞增生。将聚(PyHA)修饰的金属丝电极植入大鼠运动皮层三周,发现与未涂覆的电极相比,其显著降低了胶质细胞酸性蛋白的表达。
Surface of neural probes were electrochemically modified with a non-cell adhesive and biocompatible conjugate, pyrrole-hyaluronic acid (PyHA), to reduce reactive astrogliosis. Poly(PyHA)-modified wire electrodes were implanted into rat motor cortices for three weeks and were found to markedly reduce the expression of glial fibrillary acidic protein compared to uncoated electrodes.
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