Interplay between Hippocampal Sharp-Wave-Ripple Events and Vicarious Trial and Error Behaviors in Decision Making.
Interplay between Hippocampal Sharp-Wave-Ripple Events and Vicarious Trial and Error Behaviors in Decision Making.
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DOI：
10.1016/j.neuron.2016.10.028
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发表时间：
2016-12-07
期刊：
影响因子：
16.2
通讯作者：
Redish AD
中科院分区：
文献类型：
--
作者：
Papale AE;Zielinski MC;Frank LM;Jadhav SP;Redish AD
目前的理论认为，在经历过程中编码的记忆随后会被整合到长期存储中。海马尖波波纹 (SWR) 事件与睡眠期间的巩固过程有关，但 SWR 也会发生在清醒不动期间，其作用仍不清楚。我们报告说，奖励站点的清醒 SWR 率与替代试错（VTE）行为的盛行率呈负相关，这种行为被认为参与了深思熟虑的过程。 VTE 行为后 SWR 率立即降低，奖励部位 SWR 事件率的增加预示着选择点后续 VTE 行为的减少。此外，SWR 中断会增加 VTE 行为。这些结果表明 SWR 和 VTE 行为之间存在反比关系，并表明清醒 SWR 和相关的计划和记忆巩固机制专门在较高水平的行为确定性背景下参与。
Current theories posit that memories encoded during experiences are subsequently consolidated into longer-term storage. Hippocampal sharp-wave ripple (SWR) events have been linked to this consolidation process during sleep, but SWRs also occur during awake immobility, where their role remains unclear. We report that awake SWR rates at the reward site are inversely related to the prevalence of vicarious trial and error (VTE) behaviors, thought to be involved in deliberation processes. SWR rates were diminished immediately after VTE behaviors and an increase in the rate of SWR events at the reward site predicted a decrease in subsequent VTE behaviors at the choice point. Furthermore, SWR disruptions increased VTE behaviors. These results suggest an inverse relationship between SWRs and VTE behaviors, and suggest that awake SWRs and associated planning and memory consolidation mechanisms are engaged specifically in the context of higher levels of behavioral certainty.
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