A simple DNA gate motif for synthesizing large-scale circuits.

A simple DNA gate motif for synthesizing large-scale circuits.
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DOI:
10.1098/rsif.2010.0729
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发表时间:
2011-09-07
期刊:
Journal of the Royal Society, Interface
影响因子:
--
通讯作者:
Winfree E
Winfree E
中科院分区:
其他
文献类型:
--
作者:
Qian L;Winfree E

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对分子系统进行编程以执行复杂自主任务的前景激发了对合成生化电路设计的研究。我们特别感兴趣的是无细胞核酸系统,利用非共价杂交和链置换反应,以创建级联,实现数字和模拟电路。迄今为止,涉及最多几十个门的电路已经被实验证明。在这里,我们提出了一个简单的DNA门架构,似乎适合实际的大规模电路合成,可能涉及数千门。
The prospects of programming molecular systems to perform complex autonomous tasks have motivated research into the design of synthetic biochemical circuits. Of particular interest to us are cell-free nucleic acid systems that exploit non-covalent hybridization and strand displacement reactions to create cascades that implement digital and analogue circuits. To date, circuits involving at most tens of gates have been demonstrated experimentally. Here, we propose a simple DNA gate architecture that appears suitable for practical synthesis of large-scale circuits involving possibly thousands of gates.
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