Circulatory MIC-1 as a Determinant of Prostate Cancer Racial Disparity.
Circulatory MIC-1 as a Determinant of Prostate Cancer Racial Disparity.
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DOI：
10.3390/cancers12103033
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发表时间：
2020-10-18
期刊：
影响因子：
5.2
通讯作者：
Van Veldhuizen P
中科院分区：
文献类型：
--
作者：
Karan D;Wick J;Dubey S;Tawfik O;Van Veldhuizen P
非裔美国人被诊断出患有更具侵袭性的前列腺癌，并且比高加索人的结果更差。本研究检查了MIC-1作为风险因素的作用，并证明了种族差异前列腺癌患者循环（血清和尿液）和肿瘤组织中MIC-1差异水平的概念性观察。血清和尿液中的循环MIC-1水平在非裔美国人种族的前列腺癌患者中显著更高，具有比高加索人更高的灵敏度和特异性。在更大的患者队列中验证循环MIC-1可能有助于识别高风险前列腺癌患者，并开发以种族为导向的治疗方法，以减少种族之间观察到的癌症结果差距。在这项研究中，我们研究了MIC-1（巨噬细胞抑制性细胞因子-1）对非洲裔美国人和高加索人前列腺癌严重程度的影响。使用Mann-Whitney检验连续变量和Fisher精确检验分类变量来检查种族之间的差异。皮尔森相关系数用于确定所有样本和每个种族内连续测量值之间的关联。方差分析，包括临床参数，用于确定种族之间血清和尿液MIC-1水平的差异。我们发现两个种族在年龄（p = 0.01）、Gleason评分（p = 0.01）和疾病分期（p = 0.03）方面存在显著差异。在疾病的早期阶段，研究中的非洲裔美国人男性的Gleason评分（平均= 6.9）高于白人（平均= 6.5）。在患有前列腺癌的高加索男性中，血清MIC-1表达与年龄正相关（r = 0.7，p <0.01）。然而，非裔美国人男性具有高表达的MIC-1和高Gleason评分（r = 0.16，p = 0.3）。有趣的是，患有前列腺癌的非洲裔美国男性的尿液MIC-1水平显著高于白人患者。它似乎对非裔美国人更敏感和特异（AUC = 0.85 vs. 0.56）。因此，前列腺癌患者的高循环MIC-1可能表明MIC-1作为一种潜在的生物标志物，以提高非洲裔美国男性前列腺癌侵袭性阶段的诊断能力。然而，需要更大的样本分析队列来验证这些观察结果。
African American men are diagnosed with more aggressive prostate cancer and have worse outcomes than Caucasians. This study examined the role of MIC-1 as a risk factor and demonstrated a conceptual observation for the differential level of MIC-1 in circulation (serum and urine) and tumor tissues from prostate cancer patients of racial disparity. The circulatory MIC-1 levels in serum and urine are significantly higher in prostate cancer patients of African American ethnicity, with higher sensitivity and specificity than Caucasians. The validation of circulatory MIC-1 in a larger cohort of patients may help identify high-risk prostate cancer patients and develop race-oriented therapies to reduce the observed cancer outcome gaps between the races. In this study, we investigated the potential of MIC-1 (macrophage inhibitory cytokine-1) on the severity of prostate cancer between African American men and Caucasians. Differences between the races were examined using Mann–Whitney tests for continuous variables and Fisher’s exact tests for categorical variables. Pearson’s correlation coefficient was used to identify associations between continuous measures across all samples and within each race. Analysis of variance, including clinical parameters, was used to identify differences in serum and urine MIC-1 levels between races. We found significant differences between the two races for age (p = 0.01), Gleason scores (p = 0.01), and stage of disease (p = 0.03). African American men in the study had higher Gleason scores (mean = 6.9) than Caucasians (mean = 6.5), during earlier stages of the disease. In Caucasian men with prostate cancer, serum MIC-1 expression was positively associated with age (r = 0.7, p < 0.01). However, African American men had highly expressed MIC-1 and high Gleason scores (r = 0.16, p = 0.3). Interestingly, the urine MIC-1 level was significantly higher in African American men with prostate cancer than in Caucasian patients. It appeared to be more sensitive and specific for African Americans (AUC = 0.85 vs. 0.56). Thus, high circulatory MIC-1 in prostate cancer patients may indicate MIC-1 as a potential biomarker to improve the diagnostic ability of an aggressive stage of prostate cancer in African American men. However, a larger cohort of sample analysis is required to validate these observations.
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2.8
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