Characterizing the Neural Correlates of Response Inhibition and Error Processing in Children With Symptoms of Irritability and/or Attention-Deficit/Hyperactivity Disorder in the ABCD Study®.
Characterizing the Neural Correlates of Response Inhibition and Error Processing in Children With Symptoms of Irritability and/or Attention-Deficit/Hyperactivity Disorder in the ABCD Study®.
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DOI：
10.3389/fpsyt.2022.803891
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发表时间：
2022
影响因子：
4.7
通讯作者：
Tseng WL
中科院分区：
文献类型：
--
作者：
Lee KS;Xiao J;Luo J;Leibenluft E;Liew Z;Tseng WL
注意缺陷/多动障碍（ADHD），以注意力不集中和/或多动和冲动为特征，是一种与执行功能障碍相关的神经发育障碍，包括反应抑制和错误处理。研究记录了ADHD和儿童易怒之间的共同发生。后者的特点是情感症状，特别是频繁的脾气爆发和低挫折容忍度相对于正常发展的同龄人。儿童时期具有不同ADHD和易怒症状的青少年的共同和非共同神经相关性在很大程度上仍然未知。本研究首先将青少年大脑认知发展（ABCD）研究中的大量青少年样本在基线时根据ADHD和易怒症状（N = 11,748）划分为不同的表型组，然后在具有高质量神经影像学数据的样本子集（N = 5,948）中检查反应抑制和错误处理的共享和非共享神经相关性。潜类分析（LCA）显示4个表型组，即高度ADHD伴伴易怒症状（n = 787, 6.7%）、中度ADHD伴伴低易怒症状（n = 901, 7.7%）、高度易怒伴伴无ADHD症状（n = 279, 2.4%）和典型发育伴伴低ADHD伴低易怒症状（n = 9781, 83.3%）。潜在变量模型揭示了支持反应抑制的神经协同激活网络在额顶叶区域的组间差异，但在额和后叶区域的错误处理差异有限。这些神经差异的显著特征是，与同时出现易怒症状的ADHD青少年和反应抑制期间典型的同伴相比，仅易怒组的共激活减少。总之，本研究为ADHD、易怒及其共同发生相关的反应抑制的不同神经机制提供了初步证据。在治疗受影响的儿童和家庭时，关注ADHD和易怒症状的个体差异及其潜在机制的精准医学是有必要的。
Attention-deficit/hyperactivity disorder (ADHD), characterized by symptoms of inattention and/or hyperactivity and impulsivity, is a neurodevelopmental disorder associated with executive dysfunctions, including response inhibition and error processing. Research has documented a common co-occurrence between ADHD and pediatric irritability. The latter is more characterized by affective symptoms, specifically frequent temper outbursts and low frustration tolerance relative to typically developing peers. Shared and non-shared neural correlates of youths with varied profiles of ADHD and irritability symptoms during childhood remain largely unknown. This study first classified a large sample of youths in the Adolescent Brain Cognitive Development (ABCD) study at baseline into distinct phenotypic groups based on ADHD and irritability symptoms (N = 11,748), and then examined shared and non-shared neural correlates of response inhibition and error processing during the Stop Signal Task in a subset of sample with quality neuroimaging data (N = 5,948). Latent class analysis (LCA) revealed four phenotypic groups, i.e., high ADHD with co-occurring irritability symptoms (n = 787, 6.7%), moderate ADHD with low irritability symptoms (n = 901, 7.7%), high irritability with no ADHD symptoms (n = 279, 2.4%), and typically developing peers with low ADHD and low irritability symptoms (n = 9,781, 83.3%). Latent variable modeling revealed group differences in the neural coactivation network supporting response inhibition in the fronto-parietal regions, but limited differences in error processing across frontal and posterior regions. These neural differences were marked by decreased coactivation in the irritability only group relative to youths with ADHD and co-occurring irritability symptoms and typically developing peers during response inhibition. Together, this study provided initial evidence for differential neural mechanisms of response inhibition associated with ADHD, irritability, and their co-occurrence. Precision medicine attending to individual differences in ADHD and irritability symptoms and the underlying mechanisms are warranted when treating affected children and families.
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影响因子：
5.7
作者：
Cantlon JF
通讯作者：
Cantlon JF
影响因子：
25
作者：
Chaarani B;Hahn S;Allgaier N;Adise S;Owens MM;Juliano AC;Yuan DK;Loso H;Ivanciu A;Albaugh MD;Dumas J;Mackey S;Laurent J;Ivanova M;Hagler DJ;Cornejo MD;Hatton S;Agrawal A;Aguinaldo L;Ahonen L;Aklin W;Anokhin AP;Arroyo J;Avenevoli S;Babcock D;Bagot K;Baker FC;Banich MT;Barch DM;Bartsch H;Baskin-Sommers A;Bjork JM;Blachman-Demner D;Bloch M;Bogdan R;Bookheimer SY;Breslin F;Brown S;Calabro FJ;Calhoun V;Casey BJ;Chang L;Clark DB;Cloak C;Constable RT;Constable K;Corley R;Cottler LB;Coxe S;Dagher RK;Dale AM;Dapretto M;Delcarmen-Wiggins R;Dick AS;Do EK;Dosenbach NUF;Dowling GJ;Edwards S;Ernst TM;Fair DA;Fan CC;Feczko E;Feldstein-Ewing SW;Florsheim P;Foxe JJ;Freedman EG;Friedman NP;Friedman-Hill S;Fuemmeler BF;Galvan A;Gee DG;Giedd J;Glantz M;Glaser P;Godino J;Gonzalez M;Gonzalez R;Grant S;Gray KM;Haist F;Harms MP;Hawes S;Heath AC;Heeringa S;Heitzeg MM;Hermosillo R;Herting MM;Hettema JM;Hewitt JK;Heyser C;Hoffman E;Howlett K;Huber RS;Huestis MA;Hyde LW;Iacono WG;Infante MA;Irfanoglu O;Isaiah A;Iyengar S;Jacobus J;James R;Jean-Francois B;Jernigan T;Karcher NR;Kaufman A;Kelley B;Kit B;Ksinan A;Kuperman J;Laird AR;Larson C;LeBlanc K;Lessov-Schlagger C;Lever N;Lewis DA;Lisdahl K;Little AR;Lopez M;Luciana M;Luna B;Madden PA;Maes HH;Makowski C;Marshall AT;Mason MJ;Matochik J;McCandliss BD;McGlade E;Montoya I;Morgan G;Morris A;Mulford C;Murray P;Nagel BJ;Neale MC;Neigh G;Nencka A;Noronha A;Nixon SJ;Palmer CE;Pariyadath V;Paulus MP;Pelham WE;Pfefferbaum D;Pierpaoli C;Prescot A;Prouty D;Puttler LI;Rajapaske N;Rapuano KM;Reeves G;Renshaw PF;Riedel MC;Rojas P;de la Rosa M;Rosenberg MD;Ross MJ;Sanchez M;Schirda C;Schloesser D;Schulenberg J;Sher KJ;Sheth C;Shilling PD;Simmons WK;Sowell ER;Speer N;Spittel M;Squeglia LM;Sripada C;Steinberg J;Striley C;Sutherland MT;Tanabe J;Tapert SF;Thompson W;Tomko RL;Uban KA;Vrieze S;Wade NE;Watts R;Weiss S;Wiens BA;Williams OD;Wilbur A;Wing D;Wolff-Hughes D;Yang R;Yurgelun-Todd DA;Zucker RA;Potter A;Garavan HP;ABCD Consortium
通讯作者：
ABCD Consortium
影响因子：
4.7
作者：
Chmielewski, Witold;Bluschke, Annet;Beste, Christian
通讯作者：
Beste, Christian
影响因子：
8.2
作者：
Cooper, Shelly R.;Jackson, Joshua J.;Braver, Todd S.
通讯作者：
Braver, Todd S.
DOI：
10.1146/annurev-clinpsy-032816-044941
发表时间：
2017-01-01
期刊：
ANNUAL REVIEW OF CLINICAL PSYCHOLOGY, VOL 13
影响因子：
--
作者：
Brotman, Melissa A.;Kircanski, Katharina;Leibenluft, Ellen
通讯作者：
Leibenluft, Ellen