Patterning of the C. elegans 1° vulval lineage by RAS and Wnt pathways
Patterning of the C. elegans 1° vulval lineage by RAS and Wnt pathways
复制标题
通过 RAS 和 Wnt 途径对线虫 1° 外阴谱系进行模式化
DOI：
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发表时间：
2000
期刊：
影响因子：
--
通讯作者：
P. Sternberg
中科院分区：
文献类型：
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作者：
Minqin Wang;P. Sternberg
在秀丽隐杆线虫中，1°外阴前体的后代
In C. elegans, the descendants of the 1° vulval precursor
cell (VPC) establish a fixed spatial pattern of two different cell fates: E-F-F-E. The two inner granddaughters attach to the somatic gonadal anchor cell (AC) and generate four vulF cells, while the two outer granddaughters produce
four vulE progeny. zmp-1::GFP, a molecular marker that
distinguishes these two fates, is expressed in vulE cells, but not vulF cells. We demonstrate that a short-range AC signal is required to ensure that the pattern of vulE and vulF fates is properly established. In addition, signaling between the inner and outer 1° VPC descendants, as well as intrinsic polarity of the 1° VPC daughters, is involved in the asymmetric divisions of the 1° VPC daughters and the
proper orientation of the outcome. Finally, we provide
evidence that RAS signaling is used during this new AC
signaling event, while the Wnt receptor LIN-17 appears to
mediate signaling between the inner and outer 1° VPC
descendants.
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影响因子：
3.3
作者：
S. G. Clark;Xiaowei Lu;H. Horvitz
通讯作者：
S. G. Clark;Xiaowei Lu;H. Horvitz
某些秀丽隐杆线虫突变体的多外阴表型是由两条功能冗余途径的缺陷引起的。
影响因子：
3.3
作者：
Ferguson,EL;Horvitz,HR
通讯作者：
Horvitz,HR
秀丽隐杆线虫外阴前体细胞的能力和承诺。
DOI：
10.1006/dbio.1999.9357
发表时间：
1999
期刊：
Developmental biology.
影响因子：
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作者：
Wang,M;Sternberg,PW
通讯作者：
Sternberg,PW
影响因子：
2.7
作者：
Paul W. Sternberg;Horvitz Hr
通讯作者：
Paul W. Sternberg;Horvitz Hr
秀丽隐杆线虫外阴前体细胞细胞命运决定的细胞周期依赖性测序。
DOI：
10.1242/dev.126.9.1947
发表时间：
1999
期刊：
Development (Cambridge, England)
影响因子：
--
作者：
Ambros,V
通讯作者：
Ambros,V