Influence of gut microbiota on subclinical inflammation and insulin resistance.
Influence of gut microbiota on subclinical inflammation and insulin resistance.
复制标题
肠道菌群对亚临床炎症和胰岛素抵抗的影响。
DOI：
10.1155/2013/986734
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发表时间：
2013
影响因子：
4.6
通讯作者：
Saad MJ
中科院分区：
文献类型：
--
作者：
Carvalho BM;Saad MJ
肥胖是与胰岛素抵抗的出现相关的主要病症，胰岛素抵抗是其合并症之间的主要联系，如2型糖尿病，非酒精性脂肪肝疾病，心血管和神经退行性疾病以及几种类型的癌症。肥胖症影响着全世界大量的人;它降低了人类的健康和生活质量。在这里，我们回顾了肠道微生物群在肥胖和2型糖尿病的病理生理学中的作用，这是由营养过剩介导的细菌多样性转变促进的。由于紧密连接的降解和随之而来的肠道通透性增加，整个细菌、其产物和代谢产物通过肠道上皮细胞向循环的易位增加，最终导致炎症和胰岛素抵抗。几种专注于调节肠道微生物群的策略（抗生素、益生菌和益生元）正在实验性地用于代谢紊乱，以降低肠道通透性，增加短链脂肪酸和厌食肠道激素的产生，并促进胰岛素敏感性以抵消肥胖个体中发现的炎症状态和胰岛素抵抗。
Obesity is the main condition that is correlated with the appearance of insulin resistance, which is the major link among its comorbidities, such as type 2 diabetes, nonalcoholic fatty liver disease, cardiovascular and neurodegenerative diseases, and several types of cancer. Obesity affects a large number of individuals worldwide; it degrades human health and quality of life. Here, we review the role of the gut microbiota in the pathophysiology of obesity and type 2 diabetes, which is promoted by a bacterial diversity shift mediated by overnutrition. Whole bacteria, their products, and metabolites undergo increased translocation through the gut epithelium to the circulation due to degraded tight junctions and the consequent increase in intestinal permeability that culminates in inflammation and insulin resistance. Several strategies focusing on modulation of the gut microbiota (antibiotics, probiotics, and prebiotics) are being experimentally employed in metabolic derangement in order to reduce intestinal permeability, increase the production of short chain fatty acids and anorectic gut hormones, and promote insulin sensitivity to counteract the inflammatory status and insulin resistance found in obese individuals.
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影响因子：
82.9
作者：
Arkan, MC;Hevener, AL;Karin, M
通讯作者：
Karin, M
影响因子：
3.7
作者：
Calisto KL;Carvalho Bde M;Ropelle ER;Mittestainer FC;Camacho AC;Guadagnini D;Carvalheira JB;Saad MJ
通讯作者：
Saad MJ
影响因子：
11.1
作者：
Amar, Jacques;Chabo, Chantal;Waget, Aurelie;Klopp, Pascale;Vachoux, Christelle;Bermudez-Humaran, Luis G.;Smirnova, Natalia;Berge, Mathieu;Sulpice, Thierry;Lahtinen, Sampo;Ouwehand, Arthur;Langella, Philippe;Rautonen, Nina;Sansonetti, Philippe J.;Burcelin, Remy
通讯作者：
Burcelin, Remy
影响因子：
3.6
作者：
Andreasen, Anne Sofie;Larsen, Nadja;Pedersen, Bente Klarlund
通讯作者：
Pedersen, Bente Klarlund
影响因子：
3.7
作者：
Andersson, Anders F.;Lindberg, Mathilda;Jakobsson, Hedvig;Backhed, Fredrik;Nyren, Pal;Engstrand, Lars
通讯作者：
Engstrand, Lars