Clinical validation and assessment of a modular fluorescent imaging system and algorithm for rapid detection and quantification of dental plaque.
Clinical validation and assessment of a modular fluorescent imaging system and algorithm for rapid detection and quantification of dental plaque.
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DOI：
10.1186/s12903-017-0472-4
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发表时间：
2017-12-28
期刊：
影响因子：
2.9
通讯作者：
Yauney G
中科院分区：
文献类型：
--
作者：
Angelino K;Shah P;Edlund DA;Mohit M;Yauney G
由于口腔卫生不良，大量成人和儿童的牙菌斑未经治疗，因此患有相关的牙科和全身疾病。构建了配备 405 nm 发光二极管的手持设备来检查与牙菌斑相关的红色荧光特征的普遍程度。该装置用于对二十八名同意的人类受试者的所有四颗门牙和所有四颗犬齿进行体内成像。使用基于商业图像处理的牙菌斑成像设备在白光照明下进一步对相同区域进行成像，并由卫生员和牙医进行评估。开发了一种使用像素信息的定制计算机视觉算法，用于计算两个设备捕获的图像的斑块覆盖率，范围从 0（无斑块）到 1（完全斑块覆盖）。该算法针对成像对象计算出基于红色荧光的斑块覆盖率，范围为 0.011 至 0.211。对 405 nm 设备图像相关牙菌斑比率的临床评估和统计分析表明，与商业参考设备相比，实验设备检测牙菌斑的灵敏度和特异性较高。这款低成本开源 405 nm 设备和相关的计算机视觉算法成功捕获了与牙菌斑相关的红色荧光特征，并展示了与市售设备相当的性能。因此，为灵敏且具有成本效益的牙菌斑检测装置的构造和应用提供了概念验证。还提供了该设备的小型化移动适应性版本，以及设备组装和网络托管相关软件的分步指南，以促进开源访问具有成本效益的家庭、诊所口腔护理技术。 ClinicalTrials.gov NCT03379337，2017 年 12 月 19 日。回顾性注册。本文的在线版本（doi：10.1186/s12903-017-0472-4）包含补充材料，可供授权用户使用。
Significant numbers of adults and children have untreated plaque due to poor oral hygiene and consequently suffer from associate dental and systemic diseases. A handheld device equipped with 405 nm light-emitting diodes was constructed to examine the prevalence of red fluorescence signatures associated with dental plaque. This device was used for in vivo imaging of all four incisors and all four canines of twenty-eight consenting human subjects. The same areas were further imaged under white light illumination with a commercial image-processing based plaque-imaging device, and evaluated by a hygienist and dentist. A custom computer vision algorithm using pixel information was developed to calculate plaque coverage ratios ranging from 0 (no plaque) to 1 (complete plaque coverage) for images captured by both devices. The algorithm calculated red fluorescence-based plaque coverage ratios ranging from 0.011 to 0.211 for the subjects imaged. Clinical assessment and statistical analyses of associated plaque ratios of the 405 nm device images indicated high sensitivity and specificity in detecting dental plaque by the experimental device compared to the commercial reference device. The low-cost and open source 405 nm device and the associated computer vision algorithm successfully captured red fluorescence signatures associated with dental plaque and demonstrated comparable performance to a commercially available device. Therefore, a proof of concept validation was provided for the construction and application of a sensitive cost-effective plaque-detecting device. A miniaturized mobile adaptable version of the device was also provided, together with and a step-by-step guide for device assembly and webhost the associated software, to facilitate open-source access to a cost-effective at-home, in-clinic oral care technology. ClinicalTrials.gov NCT03379337, December 19 2017. Retrospectively registered. The online version of this article (doi: 10.1186/s12903-017-0472-4) contains supplementary material, which is available to authorized users.
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