Changing role of the amygdala in affective and cognitive traits between early and late adulthood.
Changing role of the amygdala in affective and cognitive traits between early and late adulthood.
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DOI：
10.3389/fpsyt.2023.1033543
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发表时间：
2023
影响因子：
4.7
通讯作者：
White, Stuart F.
中科院分区：
文献类型：
--
作者：
Doucet, Gaelle E.;Kruse, Jordanna A.;Hamlin, Noah;Oleson, Jacob J.;White, Stuart F.
健康的老龄化通常与认知能力下降和较低的负面影响有关。先前的研究已经报道了杏仁核在成年早期的认知和情感处理中的重要和相反的作用。然而，目前还不清楚衰老如何影响这种关系。77名健康受试者，包括40名年轻人（平均年龄= 26.1岁）和37名老年人（平均年龄= 61.8岁）完成了功能性MRI情感Stroop（AS）范式，认知电池和状态-特质焦虑量表。AS功能磁共振成像范例包括“任务试验”，参与者看到一个积极的，消极的或中性的分心图像，然后是一个数字显示，然后是另一个分心图像。我们在AS任务中提取了两个杏仁核中的信号，并在所有条件和年龄组中进行了比较。我们进一步进行了适度分析，以调查老化对杏仁核激活与焦虑或认知变量之间的关系的影响。在行为水平上，老年参与者表现出较低的特质焦虑比年轻的成年人（p = 0.002）。虽然在AS任务中总体较慢，但老年人在AS任务中实现了与年轻人相当的准确性。在大脑水平上，我们发现年龄组和杏仁核激活的试验类型之间存在显著的相互作用（F = 4.9，p = 0.03），与被动视图试验相比，老年组在最复杂的试验中表现出更强的激活。我们进一步发现，年龄显着调制焦虑和左杏仁核激活之间的关系，在负性刺激，其中年轻的成年人表现出积极的关联，而老年人表现出消极的关联。年龄也显着调制言语流畅性和左杏仁核激活之间的关系，在不一致与视图试验，与年轻人显示出负相关和老年人显示出正相关。目前的研究表明，杏仁核在情绪处理和认知特征方面的作用在成年早期和晚期之间发生变化。
Healthy aging is typically associated with cognitive decline and lower negative affect. Previous studies have reported a significant and opposite role of the amygdala in relation to cognitive and affective processing in early adulthood. However, it remains unclear how aging impacts such relationships. Seventy-seven healthy participants including 40 young (mean age = 26.1 years) and 37 older (mean age = 61.8 years) adults completed a functional MRI Affective Stroop (AS) paradigm, a cognitive battery, and the state-trait anxiety inventory. The AS fMRI paradigm included “task trials,” where participants saw a positively, negatively or neutrally valenced distractor image, followed by a numerical display, followed by another distractor image. We extracted signal in both amygdalas during the AS Task and compared it across all conditions and age group. We further conducted moderation analyses to investigate the impact of aging on the relationship between amygdala activation and anxiety or cognitive variables, respectively. At the behavioral level, older participants showed lower trait anxiety than the younger adults (p = 0.002). While overall slower during the AS task, older adults achieved comparable accuracy during the AS task, relative to the younger adults. At the brain level, we revealed a significant interaction between age group and trial types in amygdala activation (F = 4.9, p = 0.03), with the older group showing stronger activation during the most complex trials compared to the passive view trials. We further found that age significantly modulated the relationship between anxiety and the left amygdala activation during negative stimuli, where the younger adults showed a positive association while the older adults showed a negative association. Age also significantly modulated the relationship between verbal fluency and left amygdala activation during incongruent versus view trials, with the younger adults showing a negative association and the older adults showing a positive association. The current study suggests that the role of the amygdala on both emotional processing and cognitive traits changes between early and late adulthood.
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DOI：
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发表时间：
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期刊：
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影响因子：
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作者：
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影响因子：
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影响因子：
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影响因子：
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