Ventromedial prefrontal cortex is critical for the regulation of amygdala activity in humans.
Ventromedial prefrontal cortex is critical for the regulation of amygdala activity in humans.
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DOI：
10.1016/j.biopsych.2014.02.014
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发表时间：
2015-02-01
影响因子：
10.6
通讯作者：
Koenigs, Michael
中科院分区：
文献类型：
--
作者：
Motzkin, Julian C.;Philippi, Carissa L.;Wolf, Richard C.;Baskaya, Mustafa K.;Koenigs, Michael
腹内侧前额叶皮质（vmPFC）功能障碍被认为在情绪和焦虑障碍的发病机制中起着关键作用。这些疾病的主要神经回路模型提出，vmPFC的活动减退导致杏仁核活动的抑制，因此，病理性升高的负面影响水平。该模型预测，选择性丧失或减少vmPFC功能将导致杏仁核活动增强。虽然这一预测已经证实了啮齿动物病变和电生理研究使用恐惧条件反射和灭绝的范例，还没有一个明确的测试，这一预测在人类。在这项研究中，我们测试了这种预测，通过一种新的使用功能磁共振成像在n=4的神经外科患者局灶性，双边vmPFC的损害。相对于神经健康的对照组，vmPFC病变患者表现出增强杏仁核反应厌恶的图像，以及升高的静息状态杏仁核功能连接。我们观察到其他大脑区域的活动没有可比的组间差异。这些结果为vmPFC在调节人类杏仁核活动中的关键作用提供了独特的证据，并有助于阐明精神疾病背后的因果神经相互作用。
Dysfunction in ventromedial prefrontal cortex (vmPFC) is believed to play a pivotal role in the pathogenesis of mood and anxiety disorders. Leading neurocircuitry models of these disorders propose that hypoactivity in vmPFC engenders disinhibited amygdala activity, and consequently, pathologically elevated levels of negative affect. This model predicts that a selective loss or diminution of vmPFC function would result in heightened amygdala activity. While this prediction has been borne out in rodent lesion and electrophysiological studies using fear conditioning and extinction paradigms, there has not yet been a definitive test of this prediction in humans. In this study, we tested this prediction through a novel use of fMRI in n=4 neurosurgical patients with focal, bilateral vmPFC damage. Relative to neurologically healthy comparison subjects, the vmPFC lesion patients exhibited potentiated amygdala responses to aversive images as well as elevated rest-state amygdala functional connectivity. We observed no comparable group differences for activity in other brain regions. These results provide unique evidence for the critical role of vmPFC in regulating amygdala activity in humans, and help elucidate the causal neural interactions that underlie mental illness.
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影响因子：
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