Titania Nanotube Architectures Synthesized on 3D-Printed Ti-6Al-4V Implant and Assessing Vancomycin Release Protocols.
Titania Nanotube Architectures Synthesized on 3D-Printed Ti-6Al-4V Implant and Assessing Vancomycin Release Protocols.
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DOI：
10.3390/ma14216576
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发表时间：
2021-11-01
期刊：
影响因子：
--
通讯作者：
Lohwongwatana B
中科院分区：
文献类型：
--
作者：
Chunate HT;Khamwannah J;Aliyu AAA;Tantavisut S;Puncreobutr C;Khamkongkaeo A;Tongyam C;Tumkhanon K;Phetrattanarangsi T;Chanamuangkon T;Sitthiwanit T;Decha-Umphai D;Pongjirawish P;Lohwongwatana B
本研究的目的是在3D打印的Ti-6Al-4V表面上合成二氧化钛纳米管（TNT），并研究200 ppm的抗菌万古霉素药物剂量的负载，用于局部药物治疗应用24小时。通过化学表面测量和Korsmeyer-Peppas模型的线性拟合评价了合成纳米管的抗菌药物释放。通过不同时间的阳极氧化工艺在Ti-6Al-4V表面合成了纳米碳管。利用场发射扫描电子显微镜（FESEM）对纳米碳管的形貌进行了表征。采用接触角仪、傅里叶变换红外光谱仪（FTIR）和X射线光电子能谱仪（XPS）对Ti-6Al-4V表面和TNT的润湿性和化学组成进行了评估。通过高效液相色谱法（HPLC）测定了在受控气氛下200 ppm万古霉素的释放行为，因此确定了2.5 min保留时间的位置。FESEM分析证实了形成的纳米结构的TNT垂直取向，紧密堆积，光滑和无孔壁。在24 h时记录到最大累积万古霉素释放34.7%（69.5 ppm）。发现Ti-6Al-4V植入物和TNT的润湿角均低于90度。这证实了其优异的润湿性。
The aim of this study is to synthesize Titania nanotubes (TNTs) on the 3D-printed Ti-6Al-4V surface and investigate the loading of antibacterial vancomycin drug dose of 200 ppm for local drug treatment application for 24 h. The antibacterial drug release from synthesized nanotubes evaluated via the chemical surface measurement and the linear fitting of Korsmeyer–Peppas model was also assessed. The TNTs were synthesized on the Ti-6Al-4V surface through the anodization process at different anodization time. The TNTs morphology was characterized using field emission scanning electron microscope (FESEM). The wettability and the chemical composition of the Ti-6Al-4V surface and the TNTs were assessed using the contact angle meter, Fourier transform infrared spectrophotometer (FTIR) and the X-ray photoelectron spectroscopy (XPS). The vancomycin of 200 ppm release behavior under controlled atmosphere was measured by the high-performance liquid chromatography (HPLC) and hence, the position for retention time at 2.5 min was ascertained. The FESEM analysis confirmed the formation of nanostructured TNTs with vertically oriented, closely packed, smooth and unperforated walls. The maximum cumulative vancomycin release of 34.7% (69.5 ppm) was recorded at 24 h. The wetting angle of both Ti-6Al-4V implant and the TNTs were found below 90 degrees. This confirmed their excellent wettability.
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DOI：
10.1016/j.msea.2004.08.084
发表时间：
2005-01-25
影响因子：
6.4
作者：
Elmer, JW;Palmer, TA;Specht, ED
通讯作者：
Specht, ED
影响因子：
5.4
作者：
Decha-umphai, Dechawut;Chunate, H-thaichnok;Khamwannah, Jirapon
通讯作者：
Khamwannah, Jirapon
影响因子：
9.7
作者：
Das, Kakoli;Bose, Susmita;Bandyopadhyay, Amit
通讯作者：
Bandyopadhyay, Amit
影响因子：
--
作者：
Gulati K;Aw MS;Losic D
通讯作者：
Losic D
从皱褶氧化石墨烯中控制释放万古霉素的机制
影响因子：
4.1
作者：
He, Xing;Zhou, Ziyan;Su, Jiacan
通讯作者：
Su, Jiacan