Epidemiology of Bovine Tuberculosis and Its Zoonotic Implication in Addis Ababa Milkshed, Central Ethiopia.
Epidemiology of Bovine Tuberculosis and Its Zoonotic Implication in Addis Ababa Milkshed, Central Ethiopia.
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DOI：
10.3389/fvets.2021.595511
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发表时间：
2021
影响因子：
3.2
通讯作者：
Ameni G
中科院分区：
文献类型：
--
作者：
Tulu B;Zewede A;Belay M;Zeleke M;Girma M;Tegegn M;Ibrahim F;Jolliffe DA;Abebe M;Balcha TT;Gumi B;Martineau HM;Martineau AR;Ameni G
牛结核病（bTB）仍然是分布最广泛的人畜共患慢性传染病之一，对动物生产造成重大经济损失。进行了一项横断面研究，以估计在埃塞俄比亚中部分离的bTB患病率及其相关危险因素和牛分枝杆菌的类型。共有65个奶牛场和654头牛使用单一皮内比较宫颈结核素（SICCT）测试进行了bTB测试。使用结构化问卷收集了有关农场管理、动物相关特征以及饲主对bTB人畜共患重要性的认识的数据。此外，共鉴定了16只来自不同农场的动物进行尸检。采用Lowenstein Jensen （LJ）培养，对分离得到的牛支原体进行分型。采用卡方检验和logistic回归模型分析畜群和动物水平的危险因素。兽群和动物水平的bTB患病率分别为58.5% （95% CI: 46.2% ~ 69.2%）和39.3% （95% CI: 35.5% ~ 43.5%）。在畜群水平上，养殖场管理不善是bTB阳性的预测因子（p < 0.05）。动物品种、BCS差、农场类型和农场管理条件差是个体水平上bTB阳性的显著预测因子（p < 0.05）。所有动物尸检时均发现大体结核样病变。从LJ培养阳性的12只动物中共鉴定出14株牛分枝杆菌。聚集株数最多的菌株是SB1176（5株），其次是SB0134（3株）、SB0192（2株）和SB2233（2株），还有2株新菌株，每株只有1株。大多数（58.5%）受访者不知道bTB人畜共患的重要性。本研究结果表明，亚的斯亚贝巴牛棚bTB流行率较高，而牛棚主人对其传播给人类的意识水平较低。因此，需要采取可接受的结核控制措施，并提高公众对其人畜共患传播和预防措施的认识。
Bovine tuberculosis (bTB) continues to be one of the most widely distributed chronic infectious diseases of zoonotic importance, which causes a significant economic loss in animal production. A cross-sectional study was conducted to estimate the prevalence of bTB and its associated risk factors and type the Mycobacterium bovis isolated in central Ethiopia. A total of 65 dairy farms and 654 cattle were tested for bTB using a single intradermal comparative cervical tuberculin (SICCT) test. Data on farm management, animal-related characteristics, and the owner's knowledge of the zoonotic importance of bTB were collected using a structured questionnaire. In addition, a total of 16 animals from different farms were identified for postmortem examination. Lowenstein Jensen (LJ) culture was also conducted, and spoligotyping was used to type the M. bovis strains isolated. Chi-square test and logistic regression models were used to analyze the herd- and animal-level risk factors. Herd- and animal-level prevalence rates of bTB were 58.5% (95% CI: 46.2%−69.2%) and 39.3% (95% CI: 35.5%−43.5%), respectively. At the herd level, poor farm management was the predictor for bTB positivity (p < 0.05). Animal breed, poor BCS, farm type, and poor farm management conditions were significant predictors of bTB positivity (p < 0.05) at an individual animal level. All animals identified for postmortem examination were found to have gross TB-like lesions. A total of 14 M. bovis strains were identified from 12 animals that were positive for LJ culture. The strain with the largest number of clusters (five isolates) was SB1176, followed by SB0134 (three isolates), SB0192 (two isolates), and SB2233 (two isolates), and two new strains, each consisting of only one isolate. The majority (58.5%) of the respondents did not know the zoonotic importance of bTB. The result of this study showed a high prevalence of bTB in the Addis Ababa milkshed and a low level of consciousness of the owners on its transmission to humans. Therefore, the launching of acceptable control measures of bTB and the creation of public awareness about its zoonotic transmission and prevention measures are required.
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DOI：
10.1098/rstb.2010.0134
发表时间：
2010-09-27
期刊：
Philosophical transactions of the Royal Society of London. Series B, Biological sciences
影响因子：
--
作者：
Thornton PK
通讯作者：
Thornton PK
影响因子：
9.4
作者：
Kamerbeek, J;Schouls, L;vanEmbden, J
通讯作者：
vanEmbden, J
影响因子：
3.7
作者：
Dejene, Sintayehu W.;Heitkonig, Ignas M. A.;de Boer, Willem F.
通讯作者：
de Boer, Willem F.
影响因子：
3.1
作者：
Tulu, Begna;Martineau, Henny M.;Ameni, Gobena
通讯作者：
Ameni, Gobena
DOI：
10.1016/j.cimid.2012.01.003
发表时间：
2012-05
期刊：
Comparative immunology, microbiology and infectious diseases
影响因子：
--
作者：
Vordermeier M;Ameni G;Berg S;Bishop R;Robertson BD;Aseffa A;Hewinson RG;Young DB
通讯作者：
Young DB