Non-Coding RNAs as Mediators of Epigenetic Changes in Malignancies.
Non-Coding RNAs as Mediators of Epigenetic Changes in Malignancies.
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DOI：
10.3390/cancers12123657
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发表时间：
2020-12-05
期刊：
影响因子：
5.2
通讯作者：
Etchegaray JP
中科院分区：
文献类型：
--
作者：
Kumar S;Gonzalez EA;Rameshwar P;Etchegaray JP
本文讨论了非编码RNAs(NcRNAs)在癌症表观遗传学中的作用，主要集中在去调控的microRNAs(MiRNAs)和Long Non-Coding RNAs(LncRNAs)如何通过靶向表观遗传因子来改变促癌基因的表达，从而促进细胞恶性转化。讨论了使用ncRNAs作为早期预后靶点和开发与当前治疗方法结合使用的癌症治疗方法的可能性。非编码RNA(NcRNAs)是调节基因表达的未翻译的RNA分子。NcRNAs包括小核RNAs、小核仁RNAs、核糖体RNAs、转移RNAs、环状RNAs和piwi相互作用RNAs。本文综述了两种类型的ncRNAs：微小RNAs(MiRNAs)或短干扰RNAs(SiRNAs)和长非编码RNAs(LncRNAs)。我们强调了miRNAs和lncRNAs在癌症背景下影响表观基因组的机制。MiRNAs和lncRNAs都有能力与许多表观遗传修饰物和转录因子相互作用来影响基因表达。这些ncRNAs的异常表达与肿瘤的发生发展有关。它们表达失控的主要原因可以归因于表观遗传学的改变。表观遗传改变可导致ncRNAs的错误调控。实验证据表明，大多数异常表达的ncRNAs影响细胞增殖和凋亡途径，而且这种变化是癌症相关的。体外和体内实验表明，根据癌症类型的不同，ncRNAs的上调或下调都可以阻止癌症的增殖和进展。因此，更好地了解ncRNA如何影响肿瘤发生可能有助于开发新的治疗方法。在这里，我们回顾了ncRNAs在癌症表观遗传学中的作用，并强调了它们在临床治疗中的应用。
This review discusses the role of non-coding RNAs (ncRNAs) in cancer epigenetics, mostly focusing on how deregulated microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) alter the expression of cancer-promoting genes by targeting epigenetic factors to facilitate cellular malignancy. The potential for using ncRNAs as targets for early prognosis and for developing cancer therapies to be used in conjunction with current treatments is discussed. Non-coding RNAs (ncRNAs) are untranslated RNA molecules that regulate gene expressions. NcRNAs include small nuclear RNAs (snRNAs), small nucleolar RNAs (snoRNAs), ribosomal RNAs (rRNAs), transfer RNAs (tRNAs), circular RNAs (cRNAs) and piwi-interacting RNAs (piRNAs). This review focuses on two types of ncRNAs: microRNAs (miRNAs) or short interfering RNAs (siRNAs) and long non-coding RNAs (lncRNAs). We highlight the mechanisms by which miRNAs and lncRNAs impact the epigenome in the context of cancer. Both miRNAs and lncRNAs have the ability to interact with numerous epigenetic modifiers and transcription factors to influence gene expression. The aberrant expression of these ncRNAs is associated with the development and progression of tumors. The primary reason for their deregulated expression can be attributed to epigenetic alterations. Epigenetic alterations can cause the misregulation of ncRNAs. The experimental evidence indicated that most abnormally expressed ncRNAs impact cellular proliferation and apoptotic pathways, and such changes are cancer-dependent. In vitro and in vivo experiments show that, depending on the cancer type, either the upregulation or downregulation of ncRNAs can prevent the proliferation and progression of cancer. Therefore, a better understanding on how ncRNAs impact tumorigenesis could serve to develop new therapeutic treatments. Here, we review the involvement of ncRNAs in cancer epigenetics and highlight their use in clinical therapy.
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DOI：
10.1016/j.bbcan.2015.07.001
发表时间：
2015-08
期刊：
Biochimica et biophysica acta
影响因子：
--
作者：
Bhan A;Mandal SS
通讯作者：
Mandal SS
影响因子：
5.6
作者：
Braga EA;Fridman MV;Moscovtsev AA;Filippova EA;Dmitriev AA;Kushlinskii NE
通讯作者：
Kushlinskii NE
影响因子：
11.2
作者：
Bhan A;Soleimani M;Mandal SS
通讯作者：
Mandal SS
DOI：
10.1073/pnas.1016611107
发表时间：
2010-12-14
影响因子：
11.1
作者：
Bousquet, Marina;Harris, Marian H.;Lodish, Harvey F.
通讯作者：
Lodish, Harvey F.
影响因子：
64.5
作者：
Brennecke, Julius;Aravin, Alexei A.;Hannon, Gregory J.
通讯作者：
Hannon, Gregory J.