Oral Delivery of Nucleic Acid Therapies for Local and Systemic Action.
Oral Delivery of Nucleic Acid Therapies for Local and Systemic Action.
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用于局部和全身作用的核酸疗法的口服递送。
DOI：
10.1007/s11095-022-03415-7
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发表时间：
2023-01
影响因子：
3.7
通讯作者：
Oupicky, David
中科院分区：
文献类型：
--
作者：
Kumari, Neha;Siddhanta, Kasturi;Panja, Sudipta;Joshi, Vineet;Jogdeo, Chinmay;Kapoor, Ekta;Khan, Rubayat;Kollala, Sai Sundeep;Kumar, Balawant;Sil, Diptesh;Singh, Amar B.;Murry, Daryl J.;Oupicky, David
在过去的十年里，核酸疗法因其高度的选择性和比传统药物毒性最小的影响而变得越来越重要。目前，静脉注射(IV)或肌肉注射(IM)制剂构成了市场上大多数含有核酸的制剂。然而，口服给药传统上是首选的，因为给药容易，患者依从性更高。为了利用口服给药治疗NA的好处，目标NA必须被输送到目标部位，避免在其通过胃肠道的过渡过程中的所有降解和抑制因素。口服给药给NA带来了无数的挑战，使得配方开发具有挑战性。在过去的几十年里，研究人员制定了各种不同的传递系统来克服这些挑战，一些综述详细总结和讨论了这些策略。然而，有必要根据目标区分不同的方法，以便今后可以根据研究的目标制定交付战略，并有效地交付到所需地点。本综述的目的是总结靶向给药的机制，列出和讨论用于口服NA疗法的制剂策略，并描述局部和系统靶向口服给药系统的异同和当前面临的挑战。
Nucleic acid (NA) therapy has gained importance over the past decade due to its high degree of selectivity and minimal toxic effects over conventional drugs. Currently, intravenous (IV) or intramuscular (IM) formulations constitute majority of the marketed formulations containing nucleic acids. However, oral administration is traditionally preferred due to ease of administration as well as higher patient compliance. To leverage the benefits of oral delivery for NA therapy, the NA of interest must be delivered to the target site avoiding all degrading and inhibiting factors during its transition through the gastrointestinal tract. The oral route presents myriad of challenges to NA delivery, making formulation development challenging. Researchers in the last few decades have formulated various delivery systems to overcome such challenges and several reviews summarize and discuss these strategies in detail. However, there is a need to differentiate between the approaches based on target so that in future, delivery strategies can be developed according to the goal of the study and for efficient delivery to the desired site. The goal of this review is to summarize the mechanisms for target specific delivery, list and discuss the formulation strategies used for oral delivery of NA therapies and delineate the similarities and differences between local and systemic targeting oral delivery systems and current challenges.
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影响因子：
4.6
作者：
Ball RL;Bajaj P;Whitehead KA
通讯作者：
Whitehead KA
DOI：
10.1504/ijbnn.2013.054515
发表时间：
2013
期刊：
International journal of biomedical nanoscience and nanotechnology
影响因子：
--
作者：
Bergin IL;Witzmann FA
通讯作者：
Witzmann FA
影响因子：
3.7
作者：
An R;Jia Y;Wan B;Zhang Y;Dong P;Li J;Liang X
通讯作者：
Liang X
影响因子：
2.7
作者：
Braasch, DA;Paroo, Z;Corey, DR
通讯作者：
Corey, DR
DOI：
10.1152/ajpgi.2001.280.5.g922
发表时间：
2001-05-01
影响因子：
4.5
作者：
Atuma, C;Strugala, V;Holm, L
通讯作者：
Holm, L