Cerebro-Cerebellar Networks in Migraine Symptoms and Headache.
Cerebro-Cerebellar Networks in Migraine Symptoms and Headache.
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DOI：
10.3389/fpain.2022.940923
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发表时间：
2022
期刊：
影响因子：
--
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文献类型：
--
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小脑以各种方式与偏头痛的生物学联系在一起。临床上，疲劳、运动无力、眩晕、头晕、难以集中注意力和说话困难、恶心和视觉障碍等症状在不同类型的偏头痛中很常见。这些症状的神经基础是复杂的，并不完全清楚，可能涉及整个大脑中特定和共享的电路的激活。后循环中风，或神经外科手术切除后颅窝肿瘤，以及动物的解剖道追踪，为小脑功能的理论提供了第一个洞察力。如今，随着功能成像的加入，小脑结构和功能在健康和疾病方面的研究取得了很大进展，理论也因此得到了完善。因此，小脑可能是有用的，但不是执行运动、感觉或认知任务所必需的，而是通过提高与其相互连接的大脑区域产生的任务执行的速度和技能，作为神经功能的有效促进器参与其中。在皮质下水平，这些突起的关键区域是基底节和丘脑核。总而言之，小脑在多个大脑区域的调节作用似乎是引人注目的，主要是考虑到它与涉及运动、前庭、认知、情感、感觉和自主神经处理的常见神经网络相互连接的复杂性-所有功能在偏头痛谱系中都受到不同阶段和程度的影响。尽管小脑和偏头痛之间有许多联系，但目前尚不清楚这种结构是否会导致偏头痛的开始、症状的产生或头痛。通过基因驱动的兴奋性/抑制性失衡、少血症和/或白质损害风险增加而导致的特定小脑功能障碍被认为是偏头痛发病的关键因素。因此，鉴于许多脑干、中脑和前脑区域的神经投射和功能在小脑和偏头痛的三叉神经血管通路之间是共享的，本文将简要介绍小脑的结构和功能，它在三叉神经痛中的作用，以及关于小脑网络在偏头痛病理生理学中的潜在作用的相关临床和临床前文献的最新综述。
The cerebellum is associated with the biology of migraine in a variety of ways. Clinically, symptoms such as fatigue, motor weakness, vertigo, dizziness, difficulty concentrating and finding words, nausea, and visual disturbances are common in different types of migraine. The neural basis of these symptoms is complex, not completely known, and likely involve activation of both specific and shared circuits throughout the brain. Posterior circulation stroke, or neurosurgical removal of posterior fossa tumors, as well as anatomical tract tracing in animals, provided the first insights to theorize about cerebellar functions. Nowadays, with the addition of functional imaging, much progress has been done on cerebellar structure and function in health and disease, and, as a consequence, the theories refined. Accordingly, the cerebellum may be useful but not necessary for the execution of motor, sensory or cognitive tasks, but, rather, would participate as an efficiency facilitator of neurologic functions by improving speed and skill in performance of tasks produced by the cerebral area to which it is reciprocally connected. At the subcortical level, critical regions in these processes are the basal ganglia and thalamic nuclei. Altogether, a modulatory role of the cerebellum over multiple brain regions appears compelling, mainly by considering the complexity of its reciprocal connections to common neural networks involved in motor, vestibular, cognitive, affective, sensory, and autonomic processing—all functions affected at different phases and degrees across the migraine spectrum. Despite the many associations between cerebellum and migraine, it is not known whether this structure contributes to migraine initiation, symptoms generation or headache. Specific cerebellar dysfunction via genetically driven excitatory/inhibitory imbalances, oligemia and/or increased risk to white matter lesions has been proposed as a critical contributor to migraine pathogenesis. Therefore, given that neural projections and functions of many brainstem, midbrain and forebrain areas are shared between the cerebellum and migraine trigeminovascular pathways, this review will provide a synopsis on cerebellar structure and function, its role in trigeminal pain, and an updated overview of relevant clinical and preclinical literature on the potential role of cerebellar networks in migraine pathophysiology.
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影响因子：
7.7
作者：
Baek SJ;Park JS;Kim J;Yamamoto Y;Tanaka-Yamamoto K
通讯作者：
Tanaka-Yamamoto K
影响因子：
3.5
作者：
Baumann, Oliver;Borra, Ronald J.;Bower, James M.;Cullen, Kathleen E.;Habas, Christophe;Ivry, Richard B.;Leggio, Maria;Mattingley, Jason B.;Molinari, Marco;Moulton, Eric A.;Paulin, Michael G.;Pavlova, Marina A.;Schmahmann, Jeremy D.;Sokolov, Arseny A.
通讯作者：
Sokolov, Arseny A.
DOI：
10.1523/jneurosci.1984-11.2011
发表时间：
2011-09-28
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Baliki MN;Baria AT;Apkarian AV
通讯作者：
Apkarian AV
影响因子：
7.7
作者：
Balmer, Timothy S.;Trussell, Laurence O.
通讯作者：
Trussell, Laurence O.
影响因子：
2.6
作者：
Ahuja, Abhimanyu S.;Rozen, Todd D.;Atwal, Paldeep S.
通讯作者：
Atwal, Paldeep S.