Citicoline Treatment Improves Measures of Impulsivity and Task Performance in Chronic Marijuana Smokers: A Pilot BOLD fMRI Study
Citicoline Treatment Improves Measures of Impulsivity and Task Performance in Chronic Marijuana Smokers: A Pilot BOLD fMRI Study
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胞二磷胆碱治疗可改善慢性吸食大麻者的冲动和任务表现：一项 BOLD fMRI 试点研究
DOI：
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
S. Lukas
中科院分区：
文献类型：
--
作者：
S. Gruber;Kelly A Sagar;M. Dahlgren;A. Gonenç;Nina Conn;J. Winer;D. Penetar;S. Lukas
目的胞磷胆碱是一种内源性核苷酸，在历史上被用于治疗中风、创伤性脑损伤和认知功能障碍。研究还表明，胞磷胆碱治疗与物质滥用人群的认知能力改善有关。我们假设，接受胞二磷胆碱的大麻（MJ）吸烟者在认知控制任务期间，相对于接受安慰剂的人，将表现出认知能力的改善以及神经效率的提高。方法本研究通过检查胞磷胆碱对寻求治疗的慢性MJ吸烟者的影响来验证这一假设。在一项为期8周的双盲、安慰剂对照研究中，通过双盲程序将19名MJ吸烟者随机分配至胞磷胆碱组（8名男性，2名女性）或安慰剂组（9名男性，0名女性）。所有参与者在基线和治疗8周后完成了fMRI扫描，进行了两项抑制处理的认知测量，即多源干扰测试（MSIT）和Stroop颜色词测试，并完成了Barratt冲动量表（BIS-11），这是一种自我报告的冲动测量。结果：8周试验后，接受胞磷胆碱治疗的MJ吸烟者表现出明显较低的行为冲动水平，MSIT和Stroop任务的任务准确性提高，并且相对于基线水平和相对于接受安慰剂的人表现出明显不同的大脑激活模式。结论研究结果表明，胞磷胆碱可以促进MJ使用障碍的治疗，提高认知技能，充分参与全面的治疗方案。
Objective Citicoline is an endogenous nucleotide that has historically been used to treat stroke, traumatic brain injury, and cognitive dysfunction. Research has also shown that citicoline treatment is associated with improved cognitive performance in substance-abusing populations. We hypothesized that marijuana (MJ) smokers who received citicoline would demonstrate improvement in cognitive performance as well as increased neural efficiency during tasks of cognitive control relative to those who received placebo. Method The current study tested this hypothesis by examining the effects of citicoline in treatment-seeking chronic MJ smokers. In an 8-week double-blind, placebo-controlled study, 19 MJ smokers were randomly assigned via a double-blind procedure to the citicoline (8 Males, 2 Females) or placebo group (9 Males, 0 Females). All participants completed fMRI scanning at baseline and after 8 weeks of treatment during two cognitive measures of inhibitory processing, the Multi Source Interference Test (MSIT) and Stroop Color Word Test, and also completed the Barratt Impulsiveness Scale (BIS-11), a self-report measure of impulsivity. Results Following the 8 week trial, MJ smokers treated with citicoline demonstrated significantly lower levels of behavioral impulsivity, improved task accuracy on both the MSIT and Stroop tasks, and exhibited significantly different patterns of brain activation relative to baseline levels and relative to those who received placebo. Conclusions Findings suggest that citicoline may facilitate the treatment of MJ use disorders by improving the cognitive skills necessary to fully engage in comprehensive treatment programs.
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影响因子：
4.2
作者：
Matochik, JA;Eldreth, DA;Bolla, KI
通讯作者：
Bolla, KI
影响因子：
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作者：
Spiers, PA;Myers, D;Wurtman, RJ
通讯作者：
Wurtman, RJ
影响因子：
4.2
作者：
Krishnan-Sarin, Suchitra;Reynolds, Brady;Potenza, Marc N.
通讯作者：
Potenza, Marc N.
DOI：
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发表时间：
1994-12
期刊：
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
影响因子：
--
作者：
Jonathan M. Levin;B. Holman;J. Mendelson;S. Teoh;B. Garada;K. Johnson;S. Springer
通讯作者：
Jonathan M. Levin;B. Holman;J. Mendelson;S. Teoh;B. Garada;K. Johnson;S. Springer
青少年治疗寻求者的大麻戒断。
影响因子：
4.2
作者：
Vandrey,Ryan;Budney,AlanJ;Kamon,JodyL;Stanger,Catherine
通讯作者：
Stanger,Catherine