CD38: An Immunomodulatory Molecule in Inflammation and Autoimmunity.
CD38: An Immunomodulatory Molecule in Inflammation and Autoimmunity.
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DOI：
10.3389/fimmu.2020.597959
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发表时间：
2020
影响因子：
7.3
通讯作者：
Guerau-de-Arellano M
中科院分区：
文献类型：
--
作者：
Piedra-Quintero ZL;Wilson Z;Nava P;Guerau-de-Arellano M
CD38是一种可以作为酶的分子，具有NAD消耗和细胞内信号传导活性，或作为具有粘附功能的受体。CD38可以在细胞表面上表达，在那里它可以面对细胞外环境或细胞溶质，或者在细胞内区室中表达，例如内质网、核膜和线粒体。在造血细胞中观察到CD38的主要表达，在小鼠和人之间具有一些细胞类型特异性差异。CD38在免疫细胞中的作用范围从调节细胞分化到炎症期间的效应器功能，其中CD38可以调节细胞募集、细胞因子释放和NAD可用性。与炎症中的作用一致，CD38似乎也在自身免疫过程中的炎症过程中发挥关键作用，尽管CD38是否具有致病或调节作用取决于所分析的疾病、免疫细胞或动物模型。鉴于CD38生理学的复杂性，很难完全理解这种分子在自身免疫性炎症过程中的生物学。在这篇综述中，我们分析了目前的知识和争议的作用，CD38在炎症和自身免疫和新的分子工具，可以澄清目前的差距在该领域。
CD38 is a molecule that can act as an enzyme, with NAD-depleting and intracellular signaling activity, or as a receptor with adhesive functions. CD38 can be found expressed either on the cell surface, where it may face the extracellular milieu or the cytosol, or in intracellular compartments, such as endoplasmic reticulum, nuclear membrane, and mitochondria. The main expression of CD38 is observed in hematopoietic cells, with some cell-type specific differences between mouse and human. The role of CD38 in immune cells ranges from modulating cell differentiation to effector functions during inflammation, where CD38 may regulate cell recruitment, cytokine release, and NAD availability. In line with a role in inflammation, CD38 appears to also play a critical role in inflammatory processes during autoimmunity, although whether CD38 has pathogenic or regulatory effects varies depending on the disease, immune cell, or animal model analyzed. Given the complexity of the physiology of CD38 it has been difficult to completely understand the biology of this molecule during autoimmune inflammation. In this review, we analyze current knowledge and controversies regarding the role of CD38 during inflammation and autoimmunity and novel molecular tools that may clarify current gaps in the field.
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影响因子：
7.3
作者：
Brynjolfsson SF;Persson Berg L;Olsen Ekerhult T;Rimkute I;Wick MJ;Mårtensson IL;Grimsholm O
通讯作者：
Grimsholm O
影响因子：
3.7
作者：
Choe CU;Lardong K;Gelderblom M;Ludewig P;Leypoldt F;Koch-Nolte F;Gerloff C;Magnus T
通讯作者：
Magnus T
影响因子：
7.3
作者：
Anaya JM;Ramirez-Santana C;Alzate MA;Molano-Gonzalez N;Rojas-Villarraga A
通讯作者：
Rojas-Villarraga A
影响因子：
3.7
作者：
Clavarino G;Delouche N;Vettier C;Laurin D;Pernollet M;Raskovalova T;Cesbron JY;Dumestre-Pérard C;Jacob MC
通讯作者：
Jacob MC
DOI：
10.4103/1319-3767.173753
发表时间：
2016-01
期刊：
Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association
影响因子：
--
作者：
Balmus IM;Ciobica A;Trifan A;Stanciu C
通讯作者：
Stanciu C