Density of cerebellar basket and stellate cells in autism: evidence for a late developmental loss of Purkinje cells.
Density of cerebellar basket and stellate cells in autism: evidence for a late developmental loss of Purkinje cells.
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DOI：
10.1002/jnr.22056
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发表时间：
2009-08-01
影响因子：
4.2
通讯作者：
Blatt, Gene J.
中科院分区：
文献类型：
--
作者：
Whitney, Elizabeth R.;Kemper, Thomas L.;Rosene, Douglas L.;Bauman, Margaret L.;Blatt, Gene J.
小脑的改变被描述为自闭症的神经病理学特征。虽然许多研究都集中在浦肯野细胞（PC），小脑皮质的投射神经元，PC的功能是严重依赖于它们的神经支配的GABA能篮细胞（BC）和星状细胞（SC）在小脑分子层。本研究旨在确定这些抑制性中间神经元的堆积密度是否存在差异，或者这些中间神经元与PC的比例是否在自闭症患者和年龄匹配的对照组大脑中存在差异。GABA能的中间神经元，确定使用免疫组化小白蛋白（PV）在连续切片从小脑后叶的6个自闭症和4个控制的大脑，并使用体视学原理计数。可获得相邻切片上相同区域的先前PC计数，并用于计算每个PC的BC和SC数量。在这个大脑样本中，在自闭症组和对照组之间，在BC或SC的密度（分别为p=0.45和p=0.84）或每个PC的BC或SC的数量（分别为p=0.47和p=0.44）方面没有检测到统计学显著差异。在这六个自闭症病例中的至少两个和可能的三个中发现的PC数量减少的情况下，BC和SC的保存表明，在PC减少的自闭症病例中，PC产生，迁移到PC层中的适当位置，随后死亡。
Alterations in the cerebellum have been described as a neuropathological feature of autism. While numerous studies have focused on the Purkinje cell (PC), the projection neuron of the cerebellar cortex, PC function is critically dependent upon their innervation by the GABAergic basket cells (BCs) and stellate cells (SCs) in the cerebellar molecular layer. The present study was designed to determine if there are differences in the packing density of these inhibitory interneurons or if the ratio of these interneurons to PCs differs in autistic and age-matched control brains. The GABAergic interneurons were identified using immunohistochemistry for parvalbumin (PV) in serial sections from the posterior cerebellar lobe of six autistic and four control brains, and counted using stereological principles. Prior PC counts in the same area on adjacent sections were available and used to calculate the number of BCs and SCs per PC. In this sample of brains, no statistically significant difference was detected between the autistic and control groups in the density of BCs or SCs (p=0.45 and p=0.84, respectively) or in the number of BCs or SCs per PC (p=0.47 and p=0.44, respectively). The preservation of BCs and SCs, in the presence of the reduced PC numbers as found in at least two, and possibly three of these six autistic cases, suggests that PCs were generated, migrated to their proper location in the PC layer and subsequently died in the autistic cases that showed a reduction in PCs.
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影响因子：
14.5
作者：
Bailey, A;Luthert, P;Lantos, P
通讯作者：
Lantos, P
影响因子：
6.9
作者：
BAILEY, A;LECOUTEUR, A;RUTTER, M
通讯作者：
RUTTER, M
DOI：
10.1097/00004583-200106000-00011
发表时间：
2001-06-01
影响因子：
13.3
作者：
Hardan, AY;Minshew, NJ;Keshavan, MS
通讯作者：
Keshavan, MS
影响因子：
158.5
作者：
COURCHESNE, E;YEUNGCOURCHESNE, R;JERNIGAN, TL
通讯作者：
JERNIGAN, TL
影响因子：
2.2
作者：
Collins, Ann L.;Ma, Deqiong;Whitehead, Patrice L.;Martin, Eden R.;Wright, Harry H.;Abramson, Ruth K.;Hussman, John P.;Haines, Jonathan L.;Cuccaro, Michael L.;Gilbert, John R.;Pericak-Vance, Margaret A.
通讯作者：
Pericak-Vance, Margaret A.