The IS6 family, a clinically important group of insertion sequences including IS26.
The IS6 family, a clinically important group of insertion sequences including IS26.
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DOI：
10.1186/s13100-021-00239-x
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发表时间：
2021-03-23
期刊：
影响因子：
4.9
通讯作者：
Chandler M
中科院分区：
文献类型：
--
作者：
Varani A;He S;Siguier P;Ross K;Chandler M
IS 6家族的细菌和古细菌插入序列，首次发现于20世纪80年代初，已被证明是有助于重排和传播的多重抗生素耐药性。两种IS，IS 26（在许多肠细菌临床分离株中发现，作为染色体和质粒的组分）和IS 257（在革兰氏阳性菌的质粒和染色体中鉴定），因其临床影响而受到特别关注。虽然很少有生物化学数据是关于这些元素的转座机制，遗传学研究提供了一些有趣的观察表明，家庭成员可能转座使用一个意想不到的机制。在这篇综述中，我们提出了一个概述的家庭，其成员的分布和系统发育关系，其对宿主基因组的影响，并分析有关特定的转座途径，他们可能会使用现有的数据。我们还提供了一个机制模型，解释了最近的观察结果之一的IS 6家族转座途径：有针对性的复制子之间的共整合形成。在线版本包含补充材料，可通过10.1186/s13100-021-00239-x获得。
The IS6 family of bacterial and archaeal insertion sequences, first identified in the early 1980s, has proved to be instrumental in the rearrangement and spread of multiple antibiotic resistance. Two IS, IS26 (found in many enterobacterial clinical isolates as components of both chromosome and plasmids) and IS257 (identified in the plasmids and chromosomes of gram-positive bacteria), have received particular attention for their clinical impact. Although few biochemical data are available concerning the transposition mechanism of these elements, genetic studies have provided some interesting observations suggesting that members of the family might transpose using an unexpected mechanism. In this review, we present an overview of the family, the distribution and phylogenetic relationships of its members, their impact on their host genomes and analyse available data concerning the particular transposition pathways they may use. We also provide a mechanistic model that explains the recent observations on one of the IS6 family transposition pathways: targeted cointegrate formation between replicons. The online version contains supplementary material available at 10.1186/s13100-021-00239-x.
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