Trace elements in nails as biomarkers in clinical research.
Trace elements in nails as biomarkers in clinical research.
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DOI：
10.1111/j.1365-2362.2010.02373.x
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发表时间：
2011-01
影响因子：
5.5
通讯作者：
He K
中科院分区：
文献类型：
--
作者：
He K
微量元素对人体健康的重要性已越来越被人们所认识。微量元素的准确和充分定量对于临床研究至关重要。本综述旨在讨论在临床研究中使用指甲微量元素作为生物标志物的基本原理。对于大多数微量元素，膳食工具无法正确捕获摄入量，因为不同地区种植的相同食物的含量极小且差异很大，而且非膳食暴露量也很大。因此，生物标志物对于研究微量元素可能至关重要。尽管微量元素之间在生物标志物的可用性方面存在显着差异，但越来越多的证据支持指甲（尤其是脚趾甲）中大多数微量元素的浓度是有用的暴露生物标志物，其中假定单个样本代表长期暴露。与其他潜在的微量元素生物标志物相比，指甲测量在临床研究中具有一定的优势。
The importance of trace elements in relation to human health has been increasingly recognized. Accurate and adequate quantification of trace elements are crucial in clinical research. This review was to discuss the rationale of using nail trace elements as biomarkers in clinical studies. For most trace elements, dietary instruments can not appropriately capture the intakes because of the minimal amounts and wide variations in the same foods grown in different area as well as the non-dietary exposures. Therefore, biomarkers may be essential in studying trace elements. Although there are notable differences among trace elements in the availability of biomarkers, increasing evidence supports that nail particularly toenail concentrations of most trace elements are useful biomarkers of exposure in which a single sample is assumed to represent long-term exposure. As compared to other potential biomarkers of trace elements, nail measurement has certain advantages in clinical research.
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影响因子：
5
作者：
Karagas, MR;Tosteson, TD;Morris, JS
通讯作者：
Morris, JS
DOI：
10.1093/jnci/92.24.2018
发表时间：
2000-12-20
期刊：
JOURNAL OF THE NATIONAL CANCER INSTITUTE
影响因子：
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Comstock, GW
DOI：
10.1093/jnci/87.7.497
发表时间：
1995-04-05
期刊：
JOURNAL OF THE NATIONAL CANCER INSTITUTE
影响因子：
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通讯作者：
HUNTER, DJ
DOI：
10.1007/s00432-007-0266-1
发表时间：
2008-02-01
影响因子：
3.6
作者：
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通讯作者：
Nakano, Atsuhiro
影响因子：
1.9
作者：
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