Graph theory findings in the pathophysiology of temporal lobe epilepsy.
Graph theory findings in the pathophysiology of temporal lobe epilepsy.
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DOI：
10.1016/j.clinph.2014.04.004
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发表时间：
2014-07
期刊：
影响因子：
--
通讯作者：
Haneef Z
中科院分区：
文献类型：
--
作者：
Chiang S;Haneef Z
颞叶癫痫（TLE）是成人癫痫最常见的形式。越来越多的证据表明，TLE是一种异常癫痫网络的紊乱，而不是局灶性源。图论允许TLE脑网络的基于网络的表示，并有可能阐明有助于TLE病理生理学的脑拓扑结构的特征，包括癫痫发作的开始和蔓延。我们回顾的基本概念，我们相信这将证明有助于解释结果迅速出现在TLE的图论研究。此外，我们总结了目前状态的图论研究结果在颞叶癫痫，因为它们涉及其病理生理。从使用图论研究TLE的许多模式中已经出现了几个共同的发现，包括结构MRI，扩散张量成像，表面EEG，颅内EEG，脑磁图，功能MRI，细胞培养，模拟模型和小鼠模型，涉及发作间期网络配置的规则性增加，TLE网络的局部分离和全局整合改变，颞叶和边缘结构的网络重组。由于不同的方式提供了不同的观点相同的现象，未来的研究整合数据从多种方式，需要澄清的结果，并有助于形成一个连贯的理论TLE的病理生理。
Temporal lobe epilepsy (TLE) is the most common form of adult epilepsy. Accumulating evidence has shown that TLE is a disorder of abnormal epileptogenic networks, rather than focal sources. Graph theory allows for a network-based representation of TLE brain networks, and has potential to illuminate characteristics of brain topology conducive to TLE pathophysiology, including seizure initiation and spread. We review basic concepts which we believe will prove helpful in interpreting results rapidly emerging from graph theory research in TLE. In addition, we summarize the current state of graph theory findings in TLE as they pertain its pathophysiology. Several common findings have emerged from the many modalities which have been used to study TLE using graph theory, including structural MRI, diffusion tensor imaging, surface EEG, intracranial EEG, magnetoencephalography, functional MRI, cell cultures, simulated models, and mouse models, involving increased regularity of the interictal network configuration, altered local segregation and global integration of the TLE network, and network reorganization of temporal lobe and limbic structures. As different modalities provide different views of the same phenomenon, future studies integrating data from multiple modalities are needed to clarify findings and contribute to the formation of a coherent theory on the pathophysiology of TLE.
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影响因子：
5.3
作者：
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作者：
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DOI：
10.1146/annurev-clinpsy-040510-143934
发表时间：
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影响因子：
18.4
作者：
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通讯作者：
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