Explaining clustered ventilation defects via a minimal number of airway closure locations.
Explaining clustered ventilation defects via a minimal number of airway closure locations.
复制标题
DOI：
10.1007/s10439-008-9603-z
复制
发表时间：
2009-02
影响因子：
3.8
通讯作者：
Lutchen, Kenneth
中科院分区：
文献类型：
--
作者：
Mullally, William;Betke, Margrit;Albert, Mitchell;Lutchen, Kenneth
人类肺的计算模型已被开发用于研究肺生理学，并已被用于识别导致哮喘患者机械功能障碍的气道。Tgavalekos等人使用解剖学上与人肺一致的模型将通气缺陷与小气道的异质性闭合联系起来。他们的方法隐含地假设气道闭合之间的高度独立性，如映射到个体通气缺陷的气道结构的低紧凑性所指示的。然而，Venegas等人发现气道的显著相互依赖性可能在哮喘患者的斑片状通气中起作用。这使我们探索的问题，在何种程度上可以建立解剖学上一致的模型，不隐含地假设高度独立的气道，而是允许相互依赖的气道负责通气缺陷。我们提出了一种算法，用于生成受试者特定的气道树模型，最大限度地减少必须关闭或严重收缩，导致观察到的通气缺陷的气道的数量。我们还提出了新的方法来测量气道结构的紧凑性。我们的方法表明，可以建立解剖学上一致的模型，将紧凑的气道结构与通气缺陷联系起来。我们的模型还表明，一些通风缺陷可能是由关闭较大的气道比以前报道的。
Computational models of the human lung have been developed to study lung physiology and have been used to identify the airways responsible for mechanical dysfunction in asthmatics. Tgavalekos et al. used models anatomically consistent with the human lung to link ventilation defects to the heterogeneous closure of small airways. Their approach implicitly assumed a high degree of independence between airway closures as indicated by the low compactness of the airway structures mapped to individual ventilation defects. Venegas et al. however, have found that significant mutual dependence of airways may play a role in patchy ventilation of asthmatics. This led us to explore the question to what extent anatomically consistent models can be built which do not implicitly assume high independence of airways but instead allow for the mutual dependence of airways responsible for ventilation defects. We propose an algorithm for generating subject-specific airway-tree models that minimize the number of airways that must be closed or severely constricted to cause observed ventilation defects. We also propose novel approaches for measuring the compactness of airway structures. Our approach shows that anatomically consistent models which link compact airway structures to ventilation defects can be built. Our model also shows that some ventilation defects may be caused by closures of larger airways than previously reported.
登录
查看更多内容
影响因子：
3.3
作者：
DARQUENNE, C;PAIVA, M
通讯作者：
PAIVA, M
影响因子：
--
作者：
PHALEN, RF;YEH, HC;RAABE, OG
通讯作者：
RAABE, OG
影响因子：
3.8
作者：
Gillis, HL;Lutchen, KR
通讯作者：
Lutchen, KR
影响因子：
3.8
作者：
Tawhai, MH;Hunter, PJ
通讯作者：
Hunter, PJ
影响因子：
--
作者：
PHALEN, RF;OLDHAM, MJ;MORTENSEN, JD
通讯作者：
MORTENSEN, JD