Association of resistin polymorphism, its serum levels and prevalence of stroke in Japanese type 2 diabetic patients.
Association of resistin polymorphism, its serum levels and prevalence of stroke in Japanese type 2 diabetic patients.
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DOI：
10.1111/j.2040-1124.2010.00040.x
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发表时间：
2010-08-02
影响因子：
3.2
通讯作者：
Nakamura J
中科院分区：
文献类型：
--
作者：
Nakashima E;Watarai A;Tsukahara T;Hamada Y;Naruse K;Kamiya H;Kato J;Kato N;Tomita M;Oiso Y;Nakamura J
目的/简介：抵抗素是一种炎症细胞因子，可能参与动脉粥样硬化的发展。 在最近的一篇论文中，我们发现，在日本2型糖尿病患者中，cDNAn多态性可能是卒中易感性的一个危险标志。我们测试了血清中RETN水平是否也可能是独立于RETN多态性的卒中风险标志物。材料与方法：选择我院门诊2型糖尿病患者。 有冠心病和中风病史的患者（n =89）和随机选择的对照组（n= 178）在性别和年龄上相匹配，但没有冠心病和中风病史，检测多态性-420（C>G）和细胞因子水平。 结果：心血管疾病患者血清β-内酰胺酶水平显著高于非心血管疾病患者（P = 0.024），其中脑卒中患者血清β-内酰胺酶水平最高。 在多因素logistic回归分析中，即使经RETN多态性、年龄、性别、体重指数、HbA 1c、收缩压和舒张压、甘油三酯、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇、肌酐、冠心病史、胰岛素、磺脲类药物和阿司匹林治疗调整后，血清β-内酰胺酶水平仍是卒中的独立危险标志物（比值比1.33，95%置信区间[CI] 1.02-1.73，P = 0.039）。入选患者根据其血清β-内酰胺酶水平（高或低组）和基因型（-420的CC、CG、GG）分为6组。与CC和低水平组相比，GG基因型和高水平的患者显示出最高的优势比，5.69（95%CI 1.24-26.1）。结论：血清RETN水平与RETN基因多态性一样，可能是脑卒中易感性的一个良好指标。 （J Diabetes Invest，doi：10.1111/j.2040 - 1124.00040.x，2010）
Aims/Introduction: Resistin, an inflammatory cytokine, might be involved in the development of atherosclerosis. In a recent paper, we showed that resistin polymorphism might be a risk marker for stroke susceptibility in Japanese type 2 diabetic patients. We tested whether the serum resistin levels might be also a risk marker of stroke independently from RETN polymorphism. Materials and Methods: Type 2 diabetic outpatients from our hospitals were enrolled. Patients (n = 89) with a history of coronary heart disease and stroke, and randomly selected controls (n = 178) matched for sex and age, but without a history of coronary heart disease and stroke, were examined for polymorphism ‐420 (C>G) and cytokines levels. Results: Serum resistin levels were significantly higher in patients with cardiovascular diseases (CVD) than in those without CVD (P = 0.024), and were highest in patients with stroke among the CVD. In multiple logistic regression analysis, serum resistin levels was an independent risk marker of stroke even after adjusted by RETN polymorphism, age, sex, body mass index, HbA1c, systolic and diastolic blood pressure, triglyceride, low density lipoprotein cholesterol, high density lipoprotein cholesterol, creatinine, history of coronary heart disease, treatment of insulin, sulfonylurea and aspirin (odds ratio 1.33, 95% confidence interval [CI] 1.02–1.73, P = 0.039). The enrolled patients were divided by their serum resistin levels (high or low group) and their genotypes (CC, CG, GG at ‐420) into six groups. Patients with the GG genotype and high resistin levels showed the highest odds ratio, 5.69 (95% CI 1.24–26.1), compared with the group with CC and low levels. Conclusions: The results suggest that serum resistin levels might be a good marker of susceptibility to stroke as well as RETN polymorphism. (J Diabetes Invest, doi: 10.1111/j.2040‐1124.00040.x, 2010)
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影响因子：
3.2
作者：
Pilz, Stefan;Weihrauch, Gisela;Maerz, Winfried
通讯作者：
Maerz, Winfried
DOI：
10.1016/j.bbrc.2005.07.122
发表时间：
2005-09-23
影响因子：
3.1
作者：
Osawa, H;Onuma, H;Makino, H
通讯作者：
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影响因子：
7.7
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Hivert, Marie-France;Manning, Alisa K.;McAteer, Jarred B.;Dupuis, Josee;Fox, Caroline S.;Cupples, L. Adrienne;Meigs, James B.;Florez, Jose C.
通讯作者：
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影响因子：
5.3
作者：
Lim, Soo;Koo, Bo Kyeong;Park, Kyong Soo
通讯作者：
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影响因子：
9.8
作者：
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通讯作者：
Makino, H