Functional lateralization of speech processing in adults and children who stutter.
Functional lateralization of speech processing in adults and children who stutter.
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DOI：
10.3389/fpsyg.2011.00070
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发表时间：
2011
影响因子：
3.8
通讯作者：
Mazuka R
中科院分区：
文献类型：
--
作者：
Sato Y;Mori K;Koizumi T;Minagawa-Kawai Y;Tanaka A;Ozawa E;Wakaba Y;Mazuka R
发展性口吃是一种语言障碍，其特点是重复、延长和沉默障碍，特别是在话语的开头部分。虽然他们的症状与运动有关，但口吃者在大脑前部和后部语言区都表现出异常的半球优势模式。目前尚不清楚后语言区异常的功能侧化是在儿童时期开始的，还是由于多年的口吃而出现的。为了解决这个问题，我们用近红外光谱测量了成人和口吃儿童（包括学龄前儿童）在听觉言语处理过程中听觉皮层血流动力学反应的偏侧化。我们使用分析-再合成技术准备了两种类型的刺激：(i)嵌入在日语口语单词中的音位对比（/itta/ vs /itte/）和（ii）韵律对比（/itta/ vs /itta?/）。在基线块中，仅呈现/itta/令牌。在音位对比块中，/itta/和/itte/标记是伪随机呈现的，/itta/和/itta？/符号在韵律对比块。在没有口吃的成人和儿童中，左半球的音位对比明显优于韵律对比。然而，在两种刺激条件下，口吃的成人和儿童没有显著差异。一个对一个对象的分析显示，没有一个口吃者在音位对比上比韵律对比上表现出左优势。这些结果表明，即使在学龄前口吃者中，听觉言语处理的功能侧化也处于混乱状态。这些结果揭示了发育性口吃的神经病理生理学。
Developmental stuttering is a speech disorder in fluency characterized by repetitions, prolongations, and silent blocks, especially in the initial parts of utterances. Although their symptoms are motor related, people who stutter show abnormal patterns of cerebral hemispheric dominance in both anterior and posterior language areas. It is unknown whether the abnormal functional lateralization in the posterior language area starts during childhood or emerges as a consequence of many years of stuttering. In order to address this issue, we measured the lateralization of hemodynamic responses in the auditory cortex during auditory speech processing in adults and children who stutter, including preschoolers, with near-infrared spectroscopy. We used the analysis–resynthesis technique to prepare two types of stimuli: (i) a phonemic contrast embedded in Japanese spoken words (/itta/ vs. /itte/) and (ii) a prosodic contrast (/itta/ vs. /itta?/). In the baseline blocks, only /itta/ tokens were presented. In phonemic contrast blocks, /itta/ and /itte/ tokens were presented pseudo-randomly, and /itta/ and /itta?/ tokens in prosodic contrast blocks. In adults and children who do not stutter, there was a clear left-hemispheric advantage for the phonemic contrast compared to the prosodic contrast. Adults and children who stutter, however, showed no significant difference between the two stimulus conditions. A subject-by-subject analysis revealed that not a single subject who stutters showed a left advantage in the phonemic contrast over the prosodic contrast condition. These results indicate that the functional lateralization for auditory speech processing is in disarray among those who stutter, even at preschool age. These results shed light on the neural pathophysiology of developmental stuttering.
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影响因子：
4.1
作者：
BRADY, JP
通讯作者：
BRADY, JP
影响因子：
9.9
作者：
Corbera, S;Corral, MJ;Idiazábal, MA
通讯作者：
Idiazábal, MA
影响因子：
4.7
作者：
CHERRY, C;SAYERS, BM
通讯作者：
SAYERS, BM
影响因子：
5.7
作者：
Chang SE;Kenney MK;Loucks TM;Ludlow CL
通讯作者：
Ludlow CL
DOI：
10.1044/jshr.3506.1216
发表时间：
1992-12-01
期刊：
JOURNAL OF SPEECH AND HEARING RESEARCH
影响因子：
--
作者：
DENNY, M;SMITH, A
通讯作者：
SMITH, A