Brain activation abnormalities during speech and non-speech in stuttering speakers.
Brain activation abnormalities during speech and non-speech in stuttering speakers.
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DOI：
10.1016/j.neuroimage.2009.01.066
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发表时间：
2009-05-15
期刊：
影响因子：
5.7
通讯作者：
Ludlow CL
中科院分区：
文献类型：
--
作者：
Chang SE;Kenney MK;Loucks TM;Ludlow CL
虽然口吃被认为是一种语言特异性障碍，但越来越多的证据表明，口吃者在运动规划和非语言手势的执行方面存在细微的异常。我们假设，口吃的人（PWS）在运动规划和执行具有听觉目标的语音和非语音手势时，其神经反应与流利控制不同。使用稀疏采样的功能磁共振成像，单独的BOLD反应进行了测量的感知，规划，流畅的生产语音和非语音声道手势。在言语和非言语的知觉和规划，PWS有较少的激活在额叶和颞顶区相对于控制。在言语和非言语产生过程中，PWS在左侧上级颞回（STG）和左侧运动前区（BA 6）的激活低于对照组，但在右侧STG、双侧Heschl's回（HG）、海马、壳核和中央前运动区（BA 4）的激活高于对照组。PWS和对照组之间的大脑激活模式的差异在女性中最大，在男性中不太明显。总之，类似的差异PWS从控制中发现，在语音和非语音;在感知和规划，他们减少了激活，而在生产过程中，他们增加了活动的听觉区的权利和减少激活的左侧感觉运动区。这些结果表明，在PWS的神经激活差异不是语音特异性的。
Although stuttering is regarded as a speech-specific disorder, there is a growing body of evidence suggesting that subtle abnormalities in the motor planning and execution of non-speech gestures exist in stuttering individuals. We hypothesized that people who stutter (PWS) would differ from fluent controls in their neural responses during motor planning and execution of both speech and non-speech gestures that had auditory targets. Using fMRI with sparse sampling, separate BOLD responses were measured for perception, planning, and fluent production of speech and non-speech vocal tract gestures. During both speech and non-speech perception and planning, PWS had less activation in the frontal and temporoparietal regions relative to controls. During speech and non-speech production, PWS had less activation than the controls in the left superior temporal gyrus (STG) and the left pre-motor areas (BA 6) but greater activation in the right STG, bilateral Heschl’s gyrus (HG), insula, putamen, and precentral motor regions (BA 4). Differences in brain activation patterns between PWS and controls were greatest in the females and less apparent in males. In conclusion, similar differences in PWS from the controls were found during speech and non-speech; during perception and planning they had reduced activation while during production they had increased activity in the auditory area on the right and decreased activation in the left sensorimotor regions. These results demonstrated that neural activation differences in PWS are not speech-specific.
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