Epidemiology of carbapenemase-producing Enterobacteriaceae and Acinetobacter baumannii in Mediterranean countries.
Epidemiology of carbapenemase-producing Enterobacteriaceae and Acinetobacter baumannii in Mediterranean countries.
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DOI：
10.1155/2014/305784
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发表时间：
2014
影响因子：
--
通讯作者：
Lavigne JP
中科院分区：
文献类型：
--
作者：
Djahmi N;Dunyach-Remy C;Pantel A;Dekhil M;Sotto A;Lavigne JP
产生碳青霉烯酶的肠杆菌科细菌和鲍曼不动杆菌的出现和全球传播是全世界卫生服务部门非常关注的问题。这些β-内酰胺酶能降解几乎所有的β-内酰胺类抗生素，是以质粒编码的，并且很容易在细菌之间转移。它们大多是KPC、VIM、IMP、NDM和OXA-48型。它们目前在肠杆菌科的广泛传播是一个重要的令人担忧的来源。由这些细菌引起的感染治疗选择有限，并与高死亡率有关。碳青霉烯酶产生菌主要存在于肺炎克雷伯菌、大肠埃希氏菌和鲍曼不动杆菌中，目前仍主要在医院环境中存在，在社区中很少发生。地中海地区因其多样性和人口混杂而备受关注。碳青霉烯酶的流行率特别高，这一地区是最重要的储存库之一。碳青霉烯酶的类型因国家而异，部分取决于区域之间的人口交换关系和每种碳青霉烯酶可能的储存库。这篇综述描述了肠杆菌和鲍曼不动杆菌产生的碳青霉烯酶在世界这一地区的流行病学，强调了令人担忧的情况和需要筛选和检测这些酶以防止和控制它们的传播。
The emergence and global spread of carbapenemase-producing Enterobacteriaceae and Acinetobacter baumannii are of great concern to health services worldwide. These β-lactamases hydrolyse almost all β-lactams, are plasmid-encoded, and are easily transferable among bacterial species. They are mostly of the KPC, VIM, IMP, NDM, and OXA-48 types. Their current extensive spread worldwide in Enterobacteriaceae is an important source of concern. Infections caused by these bacteria have limited treatment options and have been associated with high mortality rates. Carbapenemase producers are mainly identified among Klebsiella pneumoniae, Escherichia coli, and A. baumannii and still mostly in hospital settings and rarely in the community. The Mediterranean region is of interest due to a great diversity and population mixing. The prevalence of carbapenemases is particularly high, with this area constituting one of the most important reservoirs. The types of carbapenemase vary among countries, partially depending on the population exchange relationship between the regions and the possible reservoirs of each carbapenemase. This review described the epidemiology of carbapenemases produced by enterobacteria and A. baumannii in this part of the world highlighting the worrisome situation and the need to screen and detect these enzymes to prevent and control their dissemination.
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影响因子：
11.8
作者：
Cuzon G;Naas T;Truong H;Villegas MV;Wisell KT;Carmeli Y;Gales AC;Venezia SN;Quinn JP;Nordmann P
通讯作者：
Nordmann P
影响因子：
4.9
作者：
Bonnin, Remy A.;Nordmann, Patrice;Poirel, Laurent
通讯作者：
Poirel, Laurent
影响因子：
4.9
作者：
Cuzon, Gaelle;Ouanich, Jocelyne;Nordmann, Patrice
通讯作者：
Nordmann, Patrice
影响因子：
4.9
作者：
Carrer, Amelie;Poirel, Laurent;Nordmann, Patrice
通讯作者：
Nordmann, Patrice
影响因子：
6.9
作者：
Alp, E.;Percin, D.;Gunes, T.
通讯作者：
Gunes, T.